PDE10A - phosphodiesterase 10A Gene

Species: Macaca mulatta

Gene Type: protein coding
Gene ID: 714983

About PDE10A

Primary_assembly 4: 5,018,568-5,410,026 forward strand.Mmul_10:CM014339.1

This gene has 7 transcripts (splice variants), 207 orthologues and 19 paralogues.

PDE10A Products (12)

mRNA Protein Name
XM_001105004.4 XP_001105004.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7
XM_028846987.1 XP_028702820.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_028846986.1 XP_028702819.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2
XM_028846989.1 XP_028702822.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4
XM_028846992.1 XP_028702825.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7
XM_028846988.1 XP_028702821.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_015137652.2 XP_014993138.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4
XM_015137655.2 XP_014993141.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6
XM_028846991.1 XP_028702824.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7
XM_028846985.1 XP_028702818.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1
XM_028846990.1 XP_028702823.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_015137653.2 XP_014993139.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4

PDE10A Protein Structure

GAF

GAF: pfam01590 (193 - 336)

GAF

GAF: smart00065 (369 - 524)

PDEase_I

PDEase_I: pfam00233 (616 - 847)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 882 a.a.
Protein Preferred Names Protein Names

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-50098 Mardepodect Inhibitor 98.81% Phase 2
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-14550 TP-10 Inhibitor 99.95% Phase 2
HY-153093 Elpipodect Inhibitor 98.95% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-148954 PBF-999 Antagonist 98.89% Phase 1

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W003486 5,7-Dichloropyrazolo[1,5-a]pyrimidine Inhibitor 99.69% Unkown
HY-135848 N-Methylbenzamide Inhibitor 99.93% Unkown
HY-12913 AMG 579 Inhibitor 98.95% Unkown
HY-18078 PQ-10 Inhibitor 99.41% Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-117604 THPP-1 Inhibitor 98.75% Unkown
HY-182638 CPL500036 / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-10030 Mardepodect succinate / Unkown
HY-10568 TC-E 5005 Inhibitor / Unkown
HY-116253 JNJ-42396302 Inhibitor / Unkown
HY-120022 THPP-2 Inhibitor / Unkown
HY-120291 ASP9436 Inhibitor / Unkown
HY-120945 PDE10A-IN-1 Inhibitor / Unkown
HY-123154 PDE10A-IN-4 Inhibitor / Unkown
HY-123446 JNJ-42259152 / Unkown
HY-123743 JNJ-42314415 Inhibitor / Unkown
HY-14458 SCH-1518291 Inhibitor / Unkown
HY-152838 Gemlapodect Inhibitor / Unkown
HY-153093A (1R,2R)-Elpipodect Inhibitor / Unkown
HY-158237 PDE10A-IN-3 Inhibitor / Unkown
HY-160111 PDM-042 Inhibitor / Unkown
HY-161663 Phosphodiesterase-IN-2 Inhibitor / Unkown
HY-173360 PDE10A-IN-5 Inhibitor / Unkown
HY-178987 BJH-86 Inhibitor / Unkown
HY-179645 Phosphodiesterase-IN-5 / Unkown
HY-18037 AMG-7980 / Unkown
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / Unkown
HY-124392 AMG580 Antagonist / Unkown
HY-169773 Mardepodect precursor Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PDE10A NCBI NCBI:10846