2. Gene
  3. PDE10A - phosphodiesterase 10A Gene

PDE10A - phosphodiesterase 10A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADSD2; IOLOD; HSPDE10A; PDE10A19; LINC00473

Gene ID: 10846 | Gene type: protein coding

About PDE10A

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:165,327,289-165,988,052 (from NCBI)

This gene has 40 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 5 phenotypes.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

PDE10A Products(14)

mRNA Protein Name
XM_011535388.4 XP_011533690.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_017010194.3 XP_016865683.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2
NM_006661.4 NP_006652.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_001385079.1 NP_001372008.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
XM_047418099.1 XP_047274055.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
NM_001130690.3 NP_001124162.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
XM_006715321.5 XP_006715384.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4
XM_017010195.3 XP_016865684.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418101.1 XP_047274057.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6
NR_045597.1
XM_047418100.1 XP_047274056.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418098.1 XP_047274054.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_011535387.4 XP_011533689.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1
XM_017010197.3 XP_016865686.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

PDE10A Protein Structure

GAF

GAF: GAF domain (142 - 233)

GAF

GAF: GAF domain (268 - 412)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (514 - 748)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

3',5' cAMP/cGMP phosphodiesterase

dJ416F21.1 (phosphodiesterase 10A)

phosphodiesterase 10A1 (PDE10A1)

phosphodiesterase 10A7 (PDE10A7)

Related Diseases

Diseases Alias
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Striatal Degeneration, Autosomal Dominant 2

ADSD2

Striatal Degeneration, Autosomal Dominant

Childhood-Onset Benign Chorea With Striatal Involvement

Degeneration, Striatal, Autosomal Dominant, Type 2

Hyperactive Behavior
Dyskinesia, Limb And Orofacial, Infantile-Onset

IOLOD

Infantile-Onset Generalized Dyskinesia With Orofacial Involvement

Infantile-Onset Orofacial-Trunk-Limbs Dyskinesia
Choreatic Disease

Chorea

Hereditary Chorea
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Neurodevelopmental Disorder With Involuntary Movements

NEDIM
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12472 Balipodect Inhibitor 98.91% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 95.10% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50098 Mardepodect Inhibitor 99.69% Unkown
HY-14550 TP-10 Inhibitor 99.88% Unkown
HY-153093 MK-8189 Inhibitor 99.88% Unkown
HY-12913 AMG 579 Inhibitor 99.02% Unkown
HY-117604 THPP-1 Inhibitor 98.75% Unkown
HY-18078 PQ-10 Inhibitor 99.77% Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-10568 TC-E 5005 Inhibitor / Unkown
HY-123743 JNJ-42314415 Inhibitor / Unkown
HY-135848 N-Methylbenzamide Inhibitor 99.82% Unkown
HY-152838 Gemlapodect Inhibitor / Unkown
HY-158237 PDE10A-IN-3 Inhibitor / Unkown
HY-160111 PDM-042 Inhibitor / Unkown
HY-RS10199 PDE10A Human Pre-designed siRNA Set A / Unkown
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE10A VGNC VGNC:68751
Mus musculus PDE10A MGD MGI:1345143
Rattus norvegicus PDE10A RGD RGD:68434
Bos taurus PDE10A VGNC VGNC:32668
Canis familiaris PDE10A VGNC VGNC:44345
Macaca mulatta PDE10A VGNC VGNC:75908