PDE10A - phosphodiesterase 10A Gene

Also Known as ADSD2; IOLOD; HSPDE10A; PDE10A19; LINC00473

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10846

About PDE10A

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:165,327,289-165,988,052 (from NCBI)

This gene has 40 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 5 phenotypes.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

PDE10A Products (14)

mRNA Protein Name
XM_011535388.4 XP_011533690.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_017010194.3 XP_016865683.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2
NM_006661.4 NP_006652.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_001385079.1 NP_001372008.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
XM_047418099.1 XP_047274055.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
NM_001130690.3 NP_001124162.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
XM_006715321.5 XP_006715384.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4
XM_017010195.3 XP_016865684.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418101.1 XP_047274057.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6
NR_045597.1
XM_047418100.1 XP_047274056.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418098.1 XP_047274054.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_011535387.4 XP_011533689.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1
XM_017010197.3 XP_016865686.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
IDA: Inferred from direct assay
19689430 GOA
enables cAMP binding IDA
IDA: Inferred from direct assay
19689430 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE10A Protein Structure

GAF

GAF: GAF domain (142 - 233)

GAF

GAF: GAF domain (268 - 412)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (514 - 748)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

  • 3',5' cAMP/cGMP phosphodiesterase

  • dJ416F21.1 (phosphodiesterase 10A)

  • phosphodiesterase 10A1 (PDE10A1)

  • phosphodiesterase 10A7 (PDE10A7)

Related Diseases

Diseases Alias
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Striatal Degeneration, Autosomal Dominant 2

  • ADSD2

  • Striatal Degeneration, Autosomal Dominant

  • Childhood-Onset Benign Chorea With Striatal Involvement

  • Degeneration, Striatal, Autosomal Dominant, Type 2

  • Hyperactive Behavior
Dyskinesia, Limb And Orofacial, Infantile-Onset

  • IOLOD

  • Infantile-Onset Generalized Dyskinesia With Orofacial Involvement

  • Infantile-Onset Orofacial-Trunk-Limbs Dyskinesia
Choreatic Disease

  • Chorea

  • Hereditary Chorea
Impotence

  • Erectile Dysfunction

  • Sexual Impotence

  • Erectile Dysfunction Adverse Event
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • HD

  • Huntington'S Chorea

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Neurodevelopmental Disorder With Involuntary Movements

  • NEDIM
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-50098 Mardepodect Inhibitor 99.78% Phase 2
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-14550 TP-10 Inhibitor 99.95% Phase 2
HY-153093 Elpipodect Inhibitor 98.95% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-152838 Gemlapodect Inhibitor / Phase 2
HY-12913 AMG 579 Inhibitor 98.95% Phase 1
HY-148954 PBF-999 Antagonist 98.89% Phase 1
HY-116253 JNJ-42396302 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Unkown
HY-W003486 5,7-Dichloropyrazolo[1,5-a]pyrimidine Inhibitor 99.69% Unkown
HY-135848 N-Methylbenzamide Inhibitor 99.93% Unkown
HY-18078 PQ-10 Inhibitor 99.41% Unkown
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% Unkown
HY-117604 THPP-1 Inhibitor 99.52% Unkown
HY-182638 CPL500036 / Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-10030 Mardepodect succinate / Unkown
HY-10568 TC-E 5005 Inhibitor / Unkown
HY-120022 THPP-2 Inhibitor / Unkown
HY-120291 ASP9436 Inhibitor / Unkown
HY-120945 PDE10A-IN-1 Inhibitor / Unkown
HY-123154 PDE10A-IN-4 Inhibitor / Unkown
HY-123446 JNJ-42259152 / Unkown
HY-123743 JNJ-42314415 Inhibitor / Unkown
HY-14458 SCH-1518291 Inhibitor / Unkown
HY-153093A (1R,2R)-Elpipodect Inhibitor / Unkown
HY-158237 PDE10A-IN-3 Inhibitor / Unkown
HY-160111 PDM-042 Inhibitor / Unkown
HY-161663 Phosphodiesterase-IN-2 Inhibitor / Unkown
HY-173360 PDE10A-IN-5 Inhibitor / Unkown
HY-178987 BJH-86 Inhibitor / Unkown
HY-179645 Phosphodiesterase-IN-5 / Unkown
HY-18037 AMG-7980 / Unkown
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / Unkown
HY-124392 AMG580 Antagonist / Unkown
HY-169773 Mardepodect precursor Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE10A VGNC VGNC:68751
Mus musculus PDE10A MGD MGI:1345143
Rattus norvegicus PDE10A RGD RGD:68434
Bos taurus PDE10A VGNC VGNC:32668
Canis familiaris PDE10A VGNC VGNC:44345
Macaca mulatta PDE10A VGNC VGNC:75908
Others PDE10A NCBI