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TPSAB1 - tryptase alpha/beta 1 Gene

Also Known as TPS1; TPS2; TPSB1; TPSB2; Tryptase-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7177

About TPSAB1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,240,705-1,242,554 (from NCBI)

This gene has 5 transcripts (splice variants), 841 orthologues and 3 paralogues. Biased expression in gall bladder (RPKM 111.8), lung (RPKM 108.7) and 13 other tissues.

Summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in Other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and Other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

TPSAB1 Products (1)

mRNA	Protein	Name
NM_003294.4	NP_003285.2	tryptase alpha/beta-1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	29661938	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in extracellular matrix disassembly	IDA IDA: Inferred from direct assay	27068509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPSAB1 Protein Structure

Trypsin

0
100
200
275 a.a.

Protein Preferred Names	Protein Names
tryptase alpha/beta-1	Tryptase II

TPSAB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPSAB1	Q15661	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Lumier	22046132
Intra	TPSAB1	Q15661	TPSAB1	Homo sapiens	Q15661	GMS	29661938
Intra	TPSAB1	Q15661	TPSAB1	Homo sapiens	Q15661	Comigration in SDS	29661938
Intra	TPSAB1	Q15661	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
Intra	TPSAB1	Q15661	P0C6X7-PRO_0000037318	Human SARS coronavirus	P0C6X7-PRO_0000037318	Y2H Pooling	22046132

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPSAB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71125	TPSB2 Protein, Human (HEK293, His)	AAH29356.1 (A19-P275)	≥ 95%, as determined by reducing SDS-PAGE.

TPSAB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81788	Mast Cell Tryptase Antibody (YA1533)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P84594	Mast Cell Tryptase Antibody (YA4291)	IHC-P, FC, ELISA	Human, Rat
HY-P84594A	Mast Cell Tryptase Antibody (YA4291)(PBS only)	IHC-P, FC, ELISA	Human, Rat
HY-P84595	Mast Cell Tryptase Antibody (YA4292)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84595A	Mast Cell Tryptase Antibody (YA4292)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P85811	Mast cell tryptase(PT2025) Antibody (YA5503)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85998	Mast cell tryptase Antibody (YA5690)	IHC-P, ICC/IF, ELISA	Human
HY-P86015	Mast cell tryptase Antibody (YA5707)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Mastocytosis	Mast Cell Disease Mast Cell Hyperplasia Urticaria Pigmentosa Malignant Mastocytoma Malignant Mast Cell Tumours Malignant Mastocytosis
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Hereditary Alpha Tryptasemia Syndrome
Mastocytosis, Cutaneous	Urticaria Pigmentosa Cutaneous Mastocytosis Diffuse Cutaneous Mastocytosis Maculopapular Cutaneous Mastocytosis Mastocytosis, Diffuse Cutaneous MASTC Mastocytosis, Maculopapular Cutaneous Mastocytosis, Systemic, Somatic Mastocytoma Dcm Diffuse Cutaneous Maculopapulous Mastocytosis Up/Mpcm Cm Mastocytosis, Systemic MASTSYS Mast Cell Disease Mast-Cell Disease Mast Cell Leukemia Mastocytosis, Indolent Mastocytosis With Associated Hematologic Disorder Mast Cell Neoplasm Benign Mastocytoma
Chronic Pain
Vibratory Urticaria	Vibratory Angioedema Dermodistortive Urticaria VBU Ddu Angioedema, Vibratory
Candida Glabrata	Torulopsis Glabrata
Chlorhexidine Allergy
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Solitary Mastocytoma Of The Skin	Cutaneous Solitary Mastocytoma Skin Mastocytoma Solitary Mastocytoma Solitary Mastocytoma Of Skin Mastocytoma, Skin
Physical Urticaria	Symptomatic Dermographism
Polyposis Syndrome, Hereditary Mixed, 2	HMPS2 Hereditary Mixed Polyposis Syndrome 2 Polyposis Syndrome, Mixed Hereditary 2 Polyposis Syndrome, Hereditary Mixed, Type 2
Postural Orthostatic Tachycardia Syndrome	Irritable Heart Mitral Valve Prolapse Syndrome Neurocirculatory Asthenia Orthostatic Intolerance Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orhtostatic Intolerance Postural Tachycardia Syndrome Due To Net Deficiency Soldiers Heart
Gene Duplication Disease	Gene Duplication Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14952	TPSAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19078	Tpsab1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25569	Tpsab1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990533	Anti-TPSAB1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TPSAB1	RGD	RGD:3066