Mast Cell Tryptase Antibody (YA4292)

Secreted

Tissue_specificity:Isomer 1 and isomer 2 are expressed in the lungs, stomach, spleen, heart, and skin; in these tissues, isomer 1 is dominant. Isomer 2 is expressed in aortic, splenic, and breast tumors, with the highest expression levels in endothelial cells of certain vessels around the aorta and in endothelial cells around tumors, while expression levels are very low (at the protein level) in mast cells.

Q15661 has 2 isomers: Q15661-1: 30515 Da (predicted); Q15661-2: 29533 Da (predicted).

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors, e.g. fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6

Q15661

TPS1; TPS2; TPSB1; TPSB2; Tryptase-2