Myh10 - myosin, heavy polypeptide 10, non-muscle Gene

Also Known as Fltn; NM2B; Myhn2; SMemb; Myhn-2; NMHC-B; NMMHC-B; NMHCII-B; NMHC II-B; NMMHC-IIB; mKIAA3005; NMMHC II-b; 5730504C04Rik; 9330167F11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77579

Summary

Predicted to enable several functions, including RNA binding activity; actin filament binding activity; and adenyl ribonucleotide binding activity. Involved in postsynaptic actin Cytoskeleton organization. Acts upstream of or within several processes, including animal organ development; generation of neurons; and plasma membrane repair. Located in several cellular components, including brush border; cytoskeleton; and growth cone. Part of Myosin II complex. Is active in glutamatergic synapse. Is expressed in several structures, including early embryo; eye; heart and pericardium; neural ectoderm; and respiratory system. Orthologous to human MYH10 (Myosin heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]

Myh10 Products (1)

mRNA Protein Name
NM_175260.2 NP_780469.1 myosin-10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12724421 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
16249236 MGI
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
9356462 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15880105 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
11283949 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
16481398 MGI
acts upstream of or within cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
12893741 MGI
acts upstream of or within cardiac myofibril assembly IMP
IMP: Inferred from mutant phenotype
9356462 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cerebellar Purkinje cell layer development IMP
IMP: Inferred from mutant phenotype
16481398 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
14617807 MGI
acts upstream of or within fourth ventricle development IMP
IMP: Inferred from mutant phenotype
11283949 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9356462 MGI
acts upstream of or within lateral ventricle development IMP
IMP: Inferred from mutant phenotype
9356462 MGI
acts upstream of or within mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
12893741 MGI
acts upstream of or within myofibril assembly IMP
IMP: Inferred from mutant phenotype
10712438 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
16481398 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
10712438 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
15880105 MGI
acts upstream of or within nuclear migration IMP
IMP: Inferred from mutant phenotype
16895968 MGI
acts upstream of or within plasma membrane repair IMP
IMP: Inferred from mutant phenotype
14617807 MGI
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
25220605 MGI
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25220605 MGI
acts upstream of or within regulation of cell shape IMP
IMP: Inferred from mutant phenotype
16895968 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
9356462 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IMP
IMP: Inferred from mutant phenotype
14699073 MGI
acts upstream of or within third ventricle development IMP
IMP: Inferred from mutant phenotype
11283949 MGI
acts upstream of or within ventricular cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
12893741 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15880105 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
8482409 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8482409 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
16895968 MGI
located in dendritic spine IDA
IDA: Inferred from direct assay
16481398 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25220605 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25220605 MGI
located in growth cone IDA
IDA: Inferred from direct assay
15880105 MGI
part of myosin II complex IDA
IDA: Inferred from direct assay
21126233 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
8482409 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
16012337 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
16481398 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16481398 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
12893741 MGI
located in spindle IDA
IDA: Inferred from direct assay
9725909 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
12893741 MGI
located in stress fiber IMP
IMP: Inferred from mutant phenotype
14617807 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-10

  • cellular myosin heavy chain, type B

  • flectin

  • myosin IIB

  • myosin heavy chain 10, non-muscle

  • myosin heavy chain, non-muscle IIb

  • myosin heavy chain, nonmuscular, type B

  • non-muscle myosin heavy chain B

  • non-muscle myosin heavy chain IIb

  • nonmuscle myosin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08896 MYH10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22660 Myh10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29174 Myh10 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh10 NCBI NCBI:4628