CALD1 - caldesmon 1 Gene

Also Known as CDM; HCAD; LCAD; h-CD; H-CAD; L-CAD; NAG22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 800

About CALD1

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,745,467-134,970,729 (from NCBI)

This gene has 24 transcripts (splice variants), 236 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 170.6), prostate (RPKM 164.0) and 23 other tissues.

Summary

This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to CA(2+)-calmodulin, actin, tropomyosin, Myosin, and Phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated Myosin MgATPase, and serves as a mediating factor for CA(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CALD1 Products (5)

mRNA Protein Name
NM_004342.7 NP_004333.1 caldesmon isoform 2
NM_033138.4 NP_149129.2 caldesmon isoform 1
NM_033139.4 NP_149130.1 caldesmon isoform 4
NM_033140.4 NP_149131.1 caldesmon isoform 5
NM_033157.4 NP_149347.2 caldesmon isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALD1 Protein Structure

Caldesmon

Caldesmon: Caldesmon (31 - 362)

Caldesmon

Caldesmon: Caldesmon (405 - 781)

  • 0
  • 200
  • 400
  • 600
  • 793 a.a.
Protein Preferred Names Protein Names

caldesmon

  • testis secretory sperm-binding protein Li 227n

CALD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CALD1 Q05682 SPTAN1 Homo sapiens Q13813
Anti Tag CoIP
35271311
Intra
CALD1 Q05682 SPTAN1 Homo sapiens Q13813
Crosslink
30021884
Intra
CALD1 Q05682 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
CALD1 Q05682 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

CALD1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81556 Caldesmon Antibody (YA1301) WB, IHC-P, IHC-F, IF-Tissue Human, Mouse, Rat
HY-P82587 Caldesmon Antibody (YA2332) WB, IHC-P, IP Human, Mouse, Rat
HY-P82587A Caldesmon Antibody (YA2332)(PBS only) WB, IHC-P, IP Human, Mouse, Rat
HY-P84490 Caldesmon Antibody (YA4187) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P84490A Caldesmon Antibody (YA4187)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P85837 Caldesmon Antibody (YA5529) IHC-P, WB, ICC/IF, ELISA Human
HY-P86029 Caldesmon Antibody (YA5721) IHC-P, ELISA Human
HY-P86429 Caldesmon Antibody (YA6121) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Adenomyoma
Cellular Leiomyoma
Angiomyoma

  • Vascular Leiomyoma
Cutaneous Leiomyosarcoma

  • Leiomyosarcoma Of The Skin
Glomangiomatosis
Peritoneal Benign Neoplasm
Vulvar Leiomyoma
Diffuse Peritoneal Leiomyomatosis

  • Disseminated Peritoneal Leiomyomatosis

  • Leiomyomatosis Peritonealis Disseminata

  • Dpl

  • Lpd

  • Leiomyomatosis Peritonealis Disseminate
Conventional Leiomyosarcoma
Vulvar Benign Neoplasm
Vulvar Leiomyosarcoma
Vulvar Sarcoma

  • Sarcoma Of Vulva

  • Vulva Sarcoma
Bartholin'S Duct Cyst

  • Bartholin Duct Cyst

  • Bartholin'S Cyst

  • Cyst Of Bartholin'S Gland Duct

  • Cyst Of Bartholin'S Gland

  • Vulvovaginal Cyst

  • Cyst Of Bartholin Gland Duct
Pulmonary Vein Leiomyosarcoma

  • Leiomyosarcoma Of The Pulmonary Vein
Liver Leiomyosarcoma

  • Leiomyosarcoma Of The Liver
Glomangiomyoma
Benign Perivascular Tumor

  • Benign Pericytic Neoplasm
Vaginal Endometrial Stromal Tumor
Central Nervous System Leiomyosarcoma

  • Leiomyosarcoma Of The Cns
Fallopian Tube Leiomyoma
Urethra Leiomyoma

  • Leiomyoma Of The Urethra

  • Urethral Leiomyoma
Gallbladder Leiomyosarcoma

  • Leiomyosarcoma Of The Gallbladder
Glomangioma
Myxoid Leiomyosarcoma

  • Leiomyosarcoma, Myxoid
Vagina Leiomyosarcoma

  • Leiomyosarcoma Of The Vagina

  • Vaginal Leiomyosarcoma
Vagina Leiomyoma

  • Leiomyoma Of Vagina
Breast Fibrosarcoma

  • Fibrosarcoma Of The Breast
Bizarre Leiomyoma

  • Atypical Leiomyoma

  • Pleomorphic Leiomyoma

  • Symplastic Leiomyoma
Intravascular Angioleiomyoma
Glomangiosarcoma

  • Malignant Glomus Neoplasm

  • Glomus Tumor, Malignant
Atypical Polypoid Adenomyoma
Intravascular Fasciitis

  • Intravascular Pseudosarcomatous Fasciitis
Skin Sarcoma

  • Cutaneous Sarcoma
Retroperitoneal Leiomyosarcoma
Perivascular Tumor

  • Malignant Perivascular Cancer
Heart Leiomyosarcoma

  • Leiomyosarcoma Of Heart

  • Cardiac Leiomyosarcoma
Colon Leiomyosarcoma

  • Colonic Leiomyosarcoma
Breast Leiomyosarcoma

  • Leiomyosarcoma Of The Breast
Vagina Sarcoma

  • Sarcoma Of The Vagina

  • Vaginal Sarcoma
Breast Leiomyoma
Inflammatory Leiomyosarcoma
Testicular Fibroma
Vaginal Endometrial Stromal Sarcoma
Perivascular Epithelioid Cell Tumor

  • Pecoma

  • Perivascular Epithelioid Cell Neoplasms

  • Neoplasm With Perivascular Epithelioid Cell Differentiation
Myoma

  • Muscle Benign Neoplasm

  • Myomatous Neoplasm

  • Neoplasms, Muscle Tissue

  • Benign Neoplasm Of The Muscle

  • Muscle Neoplasm

  • Muscle Tissue Neoplasm

  • Myomatous Tumor

  • Neoplasm Of Muscle

  • Muscle Neoplasms

  • Myomas
Vaginal Benign Neoplasm
Subareolar Duct Papillomatosis

  • Adenoma Of The Nipple
Nipple Benign Neoplasm

  • Tumor Of Nipple
Lung Leiomyosarcoma

  • Pulmonary Leiomyosarcoma
Retroperitoneal Sarcoma
Small Intestine Leiomyoma

  • Leiomyoma, Small Bowel

  • Leiomyoma Of Small Intestine
Breast Myofibroblastoma
Intravenous Leiomyomatosis

  • Leiomyomatosis
Conventional Fibrosarcoma
Myofibroma

  • Lipoleiomyoma

  • Uterine Fibroids

  • Solitary Myofibromatosis

  • Myolipoma
Mixed Endometrial Stromal And Smooth Muscle Tumor

  • Stromomyoma

  • Mixed Endometrial Stromal And Smooth Muscle Neoplasm
Ureter Leiomyoma

  • Ureteral Leiomyoma
Malignant Fibrous Histiocytoma Of Bone

  • Malignant Fibrous Histiocytoma Of The Bone
Fallopian Tube Benign Neoplasm
Kidney Leiomyosarcoma

  • Leiomyosarcoma Of Kidney
Epithelioid Leiomyosarcoma

  • Leiomyosarcoma Epithelioid

  • Leiomyosarcoma, Epithelioid
Subungual Glomus Tumor

  • Subungual Glomus Tumour
Deep Leiomyoma
Cervical Polyp

  • Cervix Adenomatous Polyp
Prostate Embryonal Rhabdomyosarcoma

  • Embryonal Rhabdomyosarcoma Of The Prostate
Endobronchial Leiomyoma
Gastric Leiomyoma

  • Leiomyoma Of The Stomach
Mesenchymal Cell Neoplasm

  • Benign Miscellaneous Mesenchymal Tumor

  • Mesenchymal Tumor

  • Mesenchymal Tumors
Lung Leiomyoma

  • Pulmonary Leiomyoma

  • Leiomyoma Of Lung
Small Intestine Leiomyosarcoma

  • Leiomyosarcoma Of The Small Bowel

  • Smooth Muscle Connective Tissue Tumor

  • Leiomyosarcoma Of Small Intestine
Uterus Perivascular Epithelioid Cell Tumor

  • Uterine Corpus Pecoma
Cervical Adenoma Malignum

  • Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant
Endometrial Stromal Tumor

  • Endometrial Stromal Neoplasm

  • Endometrial Stromal Tumors
Spindle Cell Lipoma
Muscle Cancer

  • Myosarcoma

  • Malignant Neoplasm Of Muscle

  • Malignant Tumor Of Muscle

  • Malignant Tumor Of The Muscle

  • Muscle Neoplasms

  • Myomatous Neoplasm
Esophagus Sarcoma

  • Esophageal Sarcoma
Pseudosarcomatous Fibromatosis

  • Nodular Fasciitis

  • Pseudosarcomatous Fasciitis

  • Fasciitis - Nodular

  • Fasciitis Nodular
Ovary Leiomyosarcoma

  • Leiomyosarcoma Of Ovary
Glomus Tumor

  • Glomus Neoplasm

  • Glomus Tumour
Connective Tissue Benign Neoplasm

  • Soft Tissue Neoplasms

  • Mesenchymal Tissue Neoplasm

  • Neoplasm Of Soft Tissue

  • Neoplasm Of Soft Tissues

  • Soft Tissue Benign Neoplasm

  • Tumor Of The Soft Tissue

  • Soft Tissue Neoplasm
Smooth Muscle Tumor
Sarcomatoid Squamous Cell Skin Carcinoma

  • Spindle Cell Squamous Cell Carcinoma

  • Spindle Cell Squamous Cell Carcinoma

  • Spindle Cell Squamous Cell Skin Carcinoma

  • Spindle Cell Squamous Carcinoma Of Skin

  • Squamous Cell Carcinoma, Sarcomatoid
Hemangiopericytoma, Malignant

  • Hemangiopericytoma

  • Haemangiopericytic Meningioma

  • Malignant Hemangiopericytoma

  • Solitary Fibrous Tumor
Ovarian Melanoma
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Spindle Cell Synovial Sarcoma

  • Synovial Sarcoma With Spindle Cell Components

  • Synovial Sarcoma, Monophasic Fibrous

  • Synovial Sarcoma, Spindle Cell
Uterine Corpus Sarcoma

  • Sarcoma Of Corpus Uteri

  • Sarcoma Of Uterus

  • Sarcoma Of The Corpus Uteri

  • Uterine Sarcoma

  • Sarcoma, Nos Of Uterus
Endometrial Stromal Nodule
Sarcomatous Intrahepatic Cholangiocarcinoma

  • Sarcomatoid Intrahepatic Cholangiocarcinoma
Reproductive Organ Benign Neoplasm
Bone Leiomyosarcoma
Benign Peritoneal Mesothelioma

  • Mesothelioma Of Peritoneum

  • Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Infiltrating Angiolipoma

  • Angiolipoma, Infiltrating
Uterine Benign Neoplasm
Lung Combined Type Small Cell Carcinoma

  • Combined Small Cell Carcinoma Of The Lung

  • Combined Type Small Cell Carcinoma Of Lung
Malignant Mesenchymoma

  • Malignant Mesenchymal Tumor

  • Mesenchymoma, Malignant

  • Sarcoma

  • Rat Malignant Renal Mesenchymal Tumor
Gastric Leiomyosarcoma

  • Leiomyosarcoma Of Stomach
Scrotum Neoplasm

  • Malignant Tumour Of Scrotum

  • Malignant Scrotal Neoplasm

  • Malignant Tumor Of Scrotum

  • Neoplasm Of Scrotum

  • Scrotal Ca

  • Scrotal Tumor

  • Scrotum Cancer

  • Cancer Of Scrotum

  • Malignant Neoplasm Of Scrotum

  • Scrotal Cancer

  • Malignant Scrotal Tumour

  • Malignant Neoplasm Of Skin Of Scrotum

  • Primary Malignant Neoplasm Of Scrotum
Liver Sarcoma

  • Hepatic Sarcoma

  • Sarcoma Of Liver
Spindle Cell Rhabdomyosarcoma
Bladder Leiomyoma

  • Leiomyoma Of The Urinary Bladder
Vascular Cancer

  • Blood Vessel Tumors

  • Malignant Vascular Neoplasm

  • Renal Vein Leiomyosarcoma

  • Vascular Neoplasms

  • Blood Vessel Neoplasm

  • Blood Vessel Tumor

  • Blood Vessel Tumour Disorder

  • Haemangiomatous Tumour

  • Leiomyosarcoma Of The Renal Vein

  • Malignant Great Vessel Tumor

  • Malignant Tumor Of Pulmonary Artery

  • Malignant Tumor Of Pulmonary Vein

  • Malignant Vascular Tumor

  • Neoplasm Of Great Vessel

  • Pulmonary Artery Malignant Neoplasm

  • Pulmonary Vein Malignant Neoplasm

  • Vascular Tissue Neoplasm

  • Vascular Tumors

  • Blood Vessel Cancer

  • Neoplasms, Vascular Tissue

  • Malignant Neoplasm Of Great Vessels
Myxofibrosarcoma

  • Fibromyxosarcoma

  • Fibromyxoid Sarcoma

  • Myxoid Malignant Fibrous Histiocytoma

  • Dermatofibrosarcoma Protuberans, Myxoid
Sarcomatosis
Extraosseous Osteosarcoma

  • Extraskeletal Osteosarcoma

  • Extraskeletal Osteogenic Sarcoma
Leiomyoma Cutis

  • Cutaneous Leiomyoma

  • Leiomyoma Of The Skin
Dermis Tumor

  • Dermis Tumour

  • Neoplasm Of Dermis

  • Tumor Of Dermis

  • Tumour Of Dermis
Urethral Benign Neoplasm

  • Urethral Neoplasms

  • Neoplasm Of Urethra

  • Neoplasm. Urethra

  • Urethral Neoplasm

  • Urethral Carcinoma

  • Malignant Neoplasm Of Urethra
Infantile Myofibromatosis

  • Lipofibromatosis

  • Myofibromatosis
Pericytoma With T(7;12)
Adenosarcoma

  • Mullerian Adenosarcoma
Heart Sarcoma

  • Cardiac Sarcoma

  • Sarcoma Of Heart
Endometrial Stromal Sarcoma

  • Ess

  • Endometrial Stromal Sarcoma, High Grade

  • Undifferentiated Endometrial Sarcoma

  • Stromal Sarcoma Of The Corpus Uteri

  • Sarcoma Endometrial Stromal

  • Sarcoma, Endometrial Stromal

  • Undifferentiated Stromal Sarcoma
Spindle Cell Sarcoma

  • Sarcoma

  • Sarcoma Spindle Cell

  • Sarcoma, Spindle Cell

  • Sarcoma - Category
Adult Fibrosarcoma
Fibrous Histiocytoma

  • Benign Fibrous Histiocytoma

  • Histiocytoma, Benign Fibrous

  • Fibroxanthoma

  • Histiocytoma Fibrous
Pulmonary Artery Leiomyosarcoma

  • Leiomyosarcoma Of The Pulmonary Artery
Prolapse Of Urethra

  • Urethrocele
Bartholin'S Gland Disease

  • Bartholin Gland Disease
Cutaneous Fibrous Histiocytoma

  • Dermatofibroma

  • Fibrohistiocytic Tumor

  • Benign Cutaneous Fibrous Histiocytoma

  • Fibrous Histiocytoma Of Skin

  • Fibrous Xanthoma Of Skin

  • Pleomorphic Fibroma

  • Sclerosing Angioma

  • Sclerosing Angioma Of Skin

  • Fibrous Histiocytoma
Congenital Granular Cell Tumor
Vaginal Cancer

  • Malignant Neoplasm Of Vagina

  • Vaginal Neoplasms

  • Malignant Tumor Of Vagina

  • Malignant Vaginal Tumor

  • Neoplasm Of Vagina

  • Vagina Neoplasm

  • Vaginal Tumor

  • Vaginal Carcinoma

  • Vaginal Malignant Epithelial Tumor

  • Vaginal Neoplasm

  • Malignant Vaginal Neoplasm

  • Vagina Carcinoma

  • Vaginal Neoplasia

  • Cancer Of Vagina

  • Malignant Tumour Of Vagina

  • Carcinoma Of Vagina

  • Primary Malignant Neoplasm Of Vagina

  • Vagina Wall Cancer

  • Vaginal Wall Cancer
Mixed Cell Type Cancer

  • Malignant Mixed Neoplasm

  • Malignant Mixed Tumor

  • Mixed Neoplasm

  • Mixed Tumor, Malignant

  • Malignant Mixed Cancer

  • Mixed Tumor

  • Malignant Mixed Tumor, Not Otherwise Specified

  • Mixed Salivary Gland Tumor

  • Mixed Tumor, Not Otherwise Specified
Lipomatosis, Multiple

  • Lipoma

  • Familial Multiple Lipomatosis

  • Lipomatosis, Familial Multiple

  • Benign Lipomatous Tumor

  • Lipomatous Neoplasm

  • Multiple Lipomatosis

  • Fml

  • Lipo

  • Benign Tumor Of Adipose Tissue

  • Lipomatous Tumor

  • Tumor Of Adipose Tissue

  • Neoplasms, Adipose Tissue

  • Lipomas
Pleomorphic Liposarcoma

  • Pls

  • Liposarcoma Pleomorphic

  • Liposarcoma, Pleomorphic
Endobronchial Lipoma
Gastric Hemangioma

  • Hemangioma Of Stomach
Sweat Gland Benign Neoplasm

  • Neoplasm Of Sweat Gland

  • Sweat Gland Tumor

  • Tumor Of The Sweat Gland

  • Sweat Gland Neoplasms

  • Sweat Gland Neoplasm
Myxosarcoma
Heart Cancer

  • Malignant Neoplasm Of Heart

  • Heart Neoplasm

  • Cardiac Tumor

  • Malignant Cardiac Tumor

  • Tumour Of Heart

  • Heart Neoplasms

  • Cardiac Carcinoma
Lung Sarcoma

  • Pulmonary Sarcoma
Myositis Ossificans

  • Myisitis Ossificans

  • Ossification - Muscle
Dedifferentiated Liposarcoma

  • Ddls

  • Liposarcoma Dedifferentiated

  • Liposarcoma, Dedifferentiated
Gastric Liposarcoma

  • Liposarcoma Of The Stomach
Solitary Fibrous Tumor/Hemangiopericytoma

  • Sft/Hpc
Cervical Adenosarcoma

  • Cervical Muellerian Adenosarcoma

  • Cervical Mullerian Adenosarcoma
Neurilemmoma

  • Schwannoma

  • Benign Schwannoma

  • Neurilemoma

  • Peripheral Fibroblastoma

  • Psammomatous Schwannoma

  • Neurolemmoma

  • Schwannomas
Well-Differentiated Liposarcoma

  • Atypical Lipomatous Tumor

  • Atypical Lipoma

  • Alt

  • Wdls

  • Liposarcoma, Well Differentiated

  • Pleomorphic Lipoma
Desmoid Tumor

  • Aggressive Fibromatosis

  • Desmoid Type Fibromatosis

  • Familial Infiltrative Fibromatosis

  • Desmoid Disorder, Hereditary

  • Fif

  • Fibromatosis, Familial Infiltrative

  • Deep Fibromatosis

  • Desmoid Fibromatosis

  • Hereditary Desmoid Disease

  • Musculoaponeurotic Fibromatosis

  • Desmoid-Type Fibromatosis

  • Fibromatosis, Aggressive

  • Desmoid Disease, Hereditary

  • Musculo-Aponeurotic Fibromatosis
Dermatofibrosarcoma Protuberans

  • DFSP

  • Dermatofibrosarcoma

  • Giant Cell Fibroblastoma

  • Metastatic Dermatofibrosarcoma Protuberans

  • Familial Dermatofibrosarcoma Protuberans

  • Darier-Ferrand Tumor

  • Darier-Hoffmann Tumor
Gastrointestinal Stromal Tumor

  • GIST

  • Gastrointestinal Stromal Tumors

  • Gastrointestinal Stromal Sarcoma

  • Gastrointestinal Stromal Tumor, Familial

  • Gant

  • Gastrointestinal Stromal Tumour

  • Stromal Tumor Of Gastrointestinal Tract

  • Stromal Tumour Of Gastrointestinal Tract

  • Gastrointestinal Stromal Neoplasm

  • Paraganglioma And Gastric Stromal Sarcoma

  • Plexosarcoma
Skeletal Muscle Cancer

  • Malignant Tumor Of Skeletal Muscle

  • Skeletal Muscle Neoplasm
Embryonal Rhabdomyosarcoma

  • Rhabdomyosarcoma, Embryonal

  • Rhabdomyosarcoma Embryonal

  • Botryoid Rhabdomyosarcoma

  • Erms

  • Spindle Cell Rhabdomyosarcomas
Muscular Disease
Chondrosarcoma, Extraskeletal Myxoid

  • Extraskeletal Myxoid Chondrosarcoma

  • Emc

  • Myxoid Extraosseous Chondrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01836 CALD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21503 Cald1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28021 Cald1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CALD1 VGNC VGNC:38666
Mus musculus CALD1 MGD MGI:88250
Macaca mulatta CALD1 VGNC VGNC:70517
Felis catus CALD1 VGNC VGNC:60322
Bos taurus CALD1 VGNC VGNC:26706
Rattus norvegicus CALD1 RGD RGD:2256
Others CALD1 NCBI