PIR - pirin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8544

About PIR

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,384,799-15,493,333 (from NCBI)

This gene has 6 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in fat (RPKM 9.0), urinary bladder (RPKM 8.0) and 24 other tissues.

Summary

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

PIR Products (2)

mRNA	Protein	Name
NM_001018109.3	NP_001018119.1	pirin
NM_003662.4	NP_003653.1	pirin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables metal ion binding	IDA IDA: Inferred from direct assay	20711196	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10362352	GOA
enables quercetin 2,3-dioxygenase activity	IDA IDA: Inferred from direct assay	15951572	GOA
enables transcription coregulator activity	IMP IMP: Inferred from mutant phenotype	23716661	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within monocyte differentiation	IMP IMP: Inferred from mutant phenotype	20010624	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20089166	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9079676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIR Protein Structure

Pirin

Pirin_C

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
pirin	pirin (iron-binding nuclear protein)

Related Diseases

Diseases	Alias
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder
Narcissistic Personality Disorder
Avoidant Personality Disorder	Anxious Personality Disorder Personality Disorders
Histrionic Personality Disorder
Schizoid Personality Disorder
Dependent Personality Disorder
Exhibitionism
Paraphilia Disorder	Paraphilia Paraphilias
Paranoid Personality Disorder
Hallucinogen Abuse
Sexual Masochism	Masochism
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Conversion Disorder	Conversion Hysteria Or Reaction Conversion Hysterical Neurosis Hysterical Neurosis, Conversion Type Fnd Functional Movement Disorder Functional Neurological Disorder Dissociative Disorder
Alexithymia
Cyclothymic Disorder	Cyclothymia Cycloid Personality Cyclothymic Personality Affective Personality Disorder Cyclothymic Personality Disorder Cycloid Personality Disorder
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Schizotypal Personality Disorder	Schizotypal Personality
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Agoraphobia	Fear Of Open Spaces Phobia Of Going Out
Gastric Cardia Carcinoma	Carcinoma Of Cardia Of Stomach
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Sexual Health Disorder	Sexual Health
Generalized Anxiety Disorder	Anxiety Generalized
Trombiculiasis
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Adjustment Disorder	Adjustment Reaction Adjustment Disorders Adjustment Disease Brief Situational Non-Psychotic Disorder Adaptation Reaction Nos Emotional Crisis Situational Disorder Situational Disturbance Situational Maladjustment Situational Reaction Situational Reaction With Maladjustment Transient Situational Disturbance
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-110085	2,2′-Dihydroxy-6,6′-dinaphthyl disulfide	Inhibitor	98.49%	Phase 4

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10571	PIR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17401	Pir Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23856	Pir Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIR	VGNC	VGNC:32915
Rattus norvegicus	PIR	RGD	RGD:1359212
Canis familiaris	PIR	VGNC	VGNC:44579
Mus musculus	PIR	MGD	MGI:1916906
Macaca mulatta	PIR	VGNC	VGNC:75893
Felis catus	PIR	VGNC	VGNC:64186
Others	PIR	NCBI