PIR - pirin Gene

Homo sapiens

Gene ID: 8544 | Gene type: protein coding

About PIR

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,384,799-15,493,333 (from NCBI)

This gene has 6 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in fat (RPKM 9.0), urinary bladder (RPKM 8.0) and 24 other tissues.

Summary

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

PIR Products(2)

mRNA	Protein	Name
NM_001018109.3	NP_001018119.1	pirin
NM_003662.4	NP_003653.1	pirin

PIR Protein Structure

Pirin

Pirin_C

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

pirin

pirin (iron-binding nuclear protein)

Related Diseases

Diseases

Alias

Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder	Obsessive-Compulsive Personality
Compulsive Personality Disorder	Ocpd
Obsessional Personality Disorder

Narcissistic Personality Disorder

Avoidant Personality Disorder

Anxious Personality Disorder

Personality Disorders

Histrionic Personality Disorder

Schizoid Personality Disorder

Dependent Personality Disorder

Exhibitionism

Paraphilia Disorder

Paraphilia

Paraphilias

Paranoid Personality Disorder

Hallucinogen Abuse

Sexual Masochism

Masochism

Hypochondriasis

Hypochondriacal Disorder	Hypochondria
Hypochondriacal Neurosis	Illness Anxiety Disorder
Health Anxiety Disorder	Hypochondriacal Reaction

Conversion Disorder

Conversion Hysteria Or Reaction	Conversion Hysterical Neurosis
Hysterical Neurosis, Conversion Type	Fnd
Functional Movement Disorder	Functional Neurological Disorder
Dissociative Disorder

Alexithymia

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Dysthymic Disorder

Dysthymia	Chronic Depressive Disorder
Chronic Depression	Depressive Personality
Depressive Personality Disorder	Persistent Depressive Disorder
Persistent Depression

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Schizotypal Personality Disorder

Schizotypal Personality

Phobia, Specific

Specific Phobia	Simple Phobia
Phobia, Simple	Isolated Phobia

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Social Phobia

Phobia, Social	Phobia Social
Phobic Anxiety Disorder

Body Dysmorphic Disorder

Dysmorphophobia	Body Dysmorphia
Dysmorphic Syndrome	Body Dysmorphic Disorders

Pathological Gambling

Compulsive Gambling	Gambling
Gambling, Pathological	Addiction
Betting	Addiction
Gambling	Betting
Pathological	Gambling
Dependence

Sexual Health Disorder

Sexual Health

Generalized Anxiety Disorder

Anxiety Generalized

Trombiculiasis

Acute Stress Disorder

Traumatic Stress Disorder	Stress Disorders, Traumatic, Acute
Stress Disorders, Traumatic

Adjustment Disorder

Adjustment Reaction	Adjustment Disorders
Adjustment Disease	Brief Situational Non-Psychotic Disorder
Adaptation Reaction Nos	Emotional Crisis
Situational Disorder	Situational Disturbance
Situational Maladjustment	Situational Reaction
Situational Reaction With Maladjustment	Transient Situational Disturbance

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110085	2,2′-Dihydroxy-6,6′-dinaphthyl disulfide	Inhibitor	/	Unkown
HY-RS10571	PIR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIR	VGNC	VGNC:32915
Rattus norvegicus	PIR	RGD	RGD:1359212
Canis familiaris	PIR	VGNC	VGNC:44579
Mus musculus	PIR	MGD	MGI:1916906
Macaca mulatta	PIR	VGNC	VGNC:75893
Felis catus	PIR	VGNC	VGNC:64186
Macaca fascicularis	PIR	NCBI
Others	PIR	NCBI