GS-9822
GS-9822 is a potent antivira agent with nanomolar activity against wild-type HIV-1 viruses. GS-9822 potently inhibits the LEDGF/p75-integrase interaction with an IC50 of 0.07 μM. GS-9822 has high in vitro metabolic stability and favorable oral pharmacokinetic profiles with low systemic clearance in rats, dogs, and monkeys.
For research use only. We do not sell to patients.
- CAS No.: 2219362-41-9
- Formula: C36H39ClN4O4S
- Molecular Weight:659.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.0022 μM (Strain IIIb), 0.0025 μM (Strain NL4.3)[1]
IC50: 0.07 μM (LEDGF/p75-integrase)[1]
Chemical Information
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CAS No. 2219362-41-9
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Molecular Weight 659.24
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Formula C36H39ClN4O4S
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SMILES
CC(C)(C)O[C@@H](C1=C(C)C=C(N=C(C2=CC=C3C(C(C4CCN(C5COC5)CC4)=NN3C)=C2)S6)C6=C1C7=CC=C(Cl)C=C7)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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