HIV-1-IN-92

Cat. No.: HY-181090: Data Sheet Handling Instructions
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HIV-1-IN-92 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase with an IC₅₀ of 0.11 μM against HIV-1 reverse transcriptase. HIV-1-IN-92 exhibits activity against both wild-type HIV-1 IIIB and mutant HIV-1 strains. HIV-1-IN-92 can be used in research related to acquired immunodeficiency syndrome (AIDS).

For research use only. We do not sell to patients.

HIV-1-IN-92 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

HIV-1

In Vitro

HIV-1-IN-92 (Compound 29) (2-5 days) inhibits HIV-1 IIIB replication in MT-4 cells (EC₅₀: 1.38 nM) and HIV-1 pNL4.3 replication in TZM-bl cells (EC₅₀: 3.50 nM)^[1].
HIV-1-IN-92 (5 days) inhibits the replication of multiple drug-resistant HIV-1 mutants in MT-4 cells, with EC₅₀ values of 1.61 nM against the K103N mutant and 119 nM against the RES056 mutant^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	Bioavailability	CL
Rat^[1]	2 mg/kg	i.v.	0.34 h	0.033 h	1454 ng/mL	344 ng·h/mL	347 ng·h/mL	/	96.2 mL/min/kg
Rat^[1]	10 mg/kg	p.o.	0.80 h	0.50 h	9.15 ng/mL	11.3 ng·h/mL	14.3 ng·h/mL	0.82 %	/

Molecular Weight

542.61

Formula

C₂₈H₂₆N₆O₄S

SMILES

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(COC3)C3=NC(NC4=CC(C#N)=C(N5CCS(CC5)(=O)=O)C=C4)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin H, et al. Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation. Bioorg Chem. 2026 Mar;170:109456. [Content Brief]

HIV-1-IN-92 Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1-IN-92HIVHuman immunodeficiency virusMT-4 cellsHIV-1 RThuman liver microsomesmutant HIV-1 strainsInhibitorinhibitorinhibit

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