HIV-1 inhibitor-43
HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression.
For research use only. We do not sell to patients.
- CAS No.: 2493426-43-8
- Formula: C24H21ClN2O4S
- Molecular Weight:468.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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HIV-1 (Y188L) 21.3 nM (EC50) |
HIV-1 (K103N+Y181C) 6.2 nM (EC50) |
HIV-1 (K103N) <0.7 nM (EC50) |
HIV-1 (Y181C) <0.7 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| MT4 | CC50 |
23818 nM
Compound: 12
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Cytotoxicity against human MT-4 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human MT-4 cells assessed as reduction in cell viability by MTT assay
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[PMID: 32883642] |
HIV-1 inhibitor-43 (compound 12) has anti-HIV-1 activity against HIV-1 reverse transcriptase with IC50s of 83±8 nM, 73±8 nM, 61±6 nM and 76±8 nM for HIV-1 WT, K103N, Y181I and K103N-Y181I, respectively[1].
HIV-1 inhibitor-43 (1, 5 and 25 nM) causes 100% reduction of HIV-1 RNA and protein p24 at 25 nM in C8166 cells infected with a WT strain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2493426-43-8
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Molecular Weight 468.95
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Formula C24H21ClN2O4S
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SMILES
O=C(C(N1)=C(S(=O)(C2=CC(C)=CC(C)=C2)=O)C3=C1C=CC(Cl)=C3)NCC4=CC=CC=C4O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-43 Related Classifications
HY-150599 Related Classifications
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