Hydrouracil-3-Ph-COOH
Based on 1 Customer Validation
Hydrouracil-3-Ph-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-3-Ph-COOH can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 2377644-59-0
- Formula: C11H10N2O4
- Molecular Weight:234.21
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2377644-59-0
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Appearance Solid
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Molecular Weight 234.21
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Formula C11H10N2O4
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC(=C1)N2C(=O)NC(=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 50 mg/mL (213.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2697 mL | 21.3484 mL | 42.6967 mL | 106.7418 mL |
| 5 mM | 0.8539 mL | 4.2697 mL | 8.5393 mL | 21.3484 mL | |
| 10 mM | 0.4270 mL | 2.1348 mL | 4.2697 mL | 10.6742 mL | |
| 15 mM | 0.2846 mL | 1.4232 mL | 2.8464 mL | 7.1161 mL | |
| 20 mM | 0.2135 mL | 1.0674 mL | 2.1348 mL | 5.3371 mL | |
| 25 mM | 0.1708 mL | 0.8539 mL | 1.7079 mL | 4.2697 mL | |
| 30 mM | 0.1423 mL | 0.7116 mL | 1.4232 mL | 3.5581 mL | |
| 40 mM | 0.1067 mL | 0.5337 mL | 1.0674 mL | 2.6685 mL | |
| 50 mM | 0.0854 mL | 0.4270 mL | 0.8539 mL | 2.1348 mL | |
| 60 mM | 0.0712 mL | 0.3558 mL | 0.7116 mL | 1.7790 mL | |
| 80 mM | 0.0534 mL | 0.2669 mL | 0.5337 mL | 1.3343 mL | |
| 100 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0674 mL |
Hydrouracil-3-Ph-COOH Related Classifications
HY-W576870 Related Classifications
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