Hydrouracil-3-Ph-COOH

Cat. No.: HY-W576870 Purity: 98.91%: Data Sheet
COA

SDS
Handling Instructions
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Hydrouracil-3-Ph-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-3-Ph-COOH can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

Hydrouracil-3-Ph-COOH Chemical Structure

CAS No. : 2377644-59-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

234.21

Formula

C₁₁H₁₀N₂O₄

CAS No.

2377644-59-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=CC(=C1)N2C(=O)NC(=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (213.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2697 mL	21.3484 mL	42.6967 mL
5 mM	0.8539 mL	4.2697 mL	8.5393 mL
10 mM	0.4270 mL	2.1348 mL	4.2697 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.91%

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Data Sheet (243 KB) SDS (393 KB)

COA (247 KB) RP-HPLC (253 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2697 mL	21.3484 mL	42.6967 mL	106.7418 mL
	5 mM	0.8539 mL	4.2697 mL	8.5393 mL	21.3484 mL
	10 mM	0.4270 mL	2.1348 mL	4.2697 mL	10.6742 mL
	15 mM	0.2846 mL	1.4232 mL	2.8464 mL	7.1161 mL
	20 mM	0.2135 mL	1.0674 mL	2.1348 mL	5.3371 mL
	25 mM	0.1708 mL	0.8539 mL	1.7079 mL	4.2697 mL
	30 mM	0.1423 mL	0.7116 mL	1.4232 mL	3.5581 mL
	40 mM	0.1067 mL	0.5337 mL	1.0674 mL	2.6685 mL
	50 mM	0.0854 mL	0.4270 mL	0.8539 mL	2.1348 mL
	60 mM	0.0712 mL	0.3558 mL	0.7116 mL	1.7790 mL
	80 mM	0.0534 mL	0.2669 mL	0.5337 mL	1.3343 mL
	100 mM	0.0427 mL	0.2135 mL	0.4270 mL	1.0674 mL