Hydrouracil-(4-Br-2,6-difluorobenzene)
Based on 1 Customer Validation
Hydrouracil-(4-Br-2,6-difluorobenzene) is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-(4-Br-2,6-difluorobenzene) can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 97.12%
- CAS No.: 1499388-70-3
- Formula: C10H7BrF2N2O2
- Molecular Weight:305.08
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1499388-70-3
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Appearance Solid
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Molecular Weight 305.08
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Formula C10H7BrF2N2O2
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Color White to off-white
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SMILES
O=C1NC(=O)CCN1C2=C(F)C=C(Br)C=C2F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (327.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (245 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2778 mL | 16.3891 mL | 32.7783 mL | 81.9457 mL |
| 5 mM | 0.6556 mL | 3.2778 mL | 6.5557 mL | 16.3891 mL | |
| 10 mM | 0.3278 mL | 1.6389 mL | 3.2778 mL | 8.1946 mL | |
| 15 mM | 0.2185 mL | 1.0926 mL | 2.1852 mL | 5.4630 mL | |
| 20 mM | 0.1639 mL | 0.8195 mL | 1.6389 mL | 4.0973 mL | |
| 25 mM | 0.1311 mL | 0.6556 mL | 1.3111 mL | 3.2778 mL | |
| 30 mM | 0.1093 mL | 0.5463 mL | 1.0926 mL | 2.7315 mL | |
| 40 mM | 0.0819 mL | 0.4097 mL | 0.8195 mL | 2.0486 mL | |
| 50 mM | 0.0656 mL | 0.3278 mL | 0.6556 mL | 1.6389 mL | |
| 60 mM | 0.0546 mL | 0.2732 mL | 0.5463 mL | 1.3658 mL | |
| 80 mM | 0.0410 mL | 0.2049 mL | 0.4097 mL | 1.0243 mL | |
| 100 mM | 0.0328 mL | 0.1639 mL | 0.3278 mL | 0.8195 mL |
Hydrouracil-(4-Br-2,6-difluorobenzene) Related Classifications
HY-48364 Related Classifications
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