Hydrouracil-(4-Br-2,6-difluorobenzene)

Cat. No.: HY-48364 Purity: 97.12%: Data Sheet
COA

SDS
Handling Instructions
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Hydrouracil-(4-Br-2,6-difluorobenzene) is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-(4-Br-2,6-difluorobenzene) can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

Hydrouracil-(4-Br-2,6-difluorobenzene) Chemical Structure

CAS No. : 1499388-70-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

305.08

Formula

C₁₀H₇BrF₂N₂O₂

CAS No.

1499388-70-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(=O)CCN1C2=C(F)C=C(Br)C=C2F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (327.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2778 mL	16.3891 mL	32.7783 mL
5 mM	0.6556 mL	3.2778 mL	6.5557 mL
10 mM	0.3278 mL	1.6389 mL	3.2778 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.12%

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Data Sheet (245 KB) SDS (394 KB)

COA (250 KB) HNMR (249 KB) LCMS (334 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2778 mL	16.3891 mL	32.7783 mL	81.9457 mL
	5 mM	0.6556 mL	3.2778 mL	6.5557 mL	16.3891 mL
	10 mM	0.3278 mL	1.6389 mL	3.2778 mL	8.1946 mL
	15 mM	0.2185 mL	1.0926 mL	2.1852 mL	5.4630 mL
	20 mM	0.1639 mL	0.8195 mL	1.6389 mL	4.0973 mL
	25 mM	0.1311 mL	0.6556 mL	1.3111 mL	3.2778 mL
	30 mM	0.1093 mL	0.5463 mL	1.0926 mL	2.7315 mL
	40 mM	0.0819 mL	0.4097 mL	0.8195 mL	2.0486 mL
	50 mM	0.0656 mL	0.3278 mL	0.6556 mL	1.6389 mL
	60 mM	0.0546 mL	0.2732 mL	0.5463 mL	1.3658 mL
	80 mM	0.0410 mL	0.2049 mL	0.4097 mL	1.0243 mL
	100 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8195 mL