Immepip

Cat. No.: HY-101321 Purity: 99.05%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases.

For research use only. We do not sell to patients.

Immepip Chemical Structure

CAS No. : 151070-83-6

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Other Forms of Immepip:

Immepip dihydrobromide In-stock

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.67 nM Compound: 3	Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding	[PMID: 20690643]
CHO-K1	EC₅₀	0.67 nM Compound: 2, Immepip	Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillation counting Agonist activity at human recombinant histamine H3 receptor expressed in CHO-K1 cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillation counting	[PMID: 20541426]

In Vivo

Immepip (i.p.; 5, 10 mg/kg) markedly reduces cortical histamine release, but only weakly promotes sleep in the rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	5, 10 mg/kg
Administration:	Intraperitoneally
Result:	Significantly modulated brain histamine release and slight, albeit significant, decreased in sleep onset latency.

Molecular Weight

165.24

Formula

C₉H₁₅N₃

CAS No.

151070-83-6

Appearance

Solid

Color

White to off-white

SMILES

C1(CC2=CN=CN2)CCNCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (302.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0518 mL	30.2590 mL	60.5180 mL
5 mM	1.2104 mL	6.0518 mL	12.1036 mL
10 mM	0.6052 mL	3.0259 mL	6.0518 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.05%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (259 KB) RP-HPLC (276 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Yves Lamberty, et al. H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat. Pharmacol Res. 2003 Aug;48(2):193-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.0518 mL	30.2590 mL	60.5180 mL	151.2951 mL
	5 mM	1.2104 mL	6.0518 mL	12.1036 mL	30.2590 mL
	10 mM	0.6052 mL	3.0259 mL	6.0518 mL	15.1295 mL
	15 mM	0.4035 mL	2.0173 mL	4.0345 mL	10.0863 mL
	20 mM	0.3026 mL	1.5130 mL	3.0259 mL	7.5648 mL
	25 mM	0.2421 mL	1.2104 mL	2.4207 mL	6.0518 mL
	30 mM	0.2017 mL	1.0086 mL	2.0173 mL	5.0432 mL
	40 mM	0.1513 mL	0.7565 mL	1.5130 mL	3.7824 mL
	50 mM	0.1210 mL	0.6052 mL	1.2104 mL	3.0259 mL
	60 mM	0.1009 mL	0.5043 mL	1.0086 mL	2.5216 mL
	80 mM	0.0756 mL	0.3782 mL	0.7565 mL	1.8912 mL
	100 mM	0.0605 mL	0.3026 mL	0.6052 mL	1.5130 mL

Immepip Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Immepip151070-83-6Histamine ReceptorH3cortical histamineneurological diseasesInhibitorinhibitorinhibit

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