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HTR5A - 5-hydroxytryptamine receptor 5A Gene

Also Known as 5-HT5A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3361

About HTR5A

Cytogenetic location: 7q36.2 Genomic coordinates (GRCh38): 7:155,070,324-155,087,392 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 8 paralogues. Restricted expression toward brain (RPKM 2.3).

Summary

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

HTR5A Products (1)

mRNA	Protein	Name
NM_024012.4	NP_076917.1	5-hydroxytryptamine receptor 5A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7988681	GOA
enables Gi/o-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	9865521	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	9865521	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	9865521	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	9865521	GOA
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	9865521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR5A Protein Structure

7tm_1

0
100
200
300
357 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 5A	5-HT-5 5-HT-5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

Related Diseases

Diseases	Alias
Sacral Defect With Anterior Meningocele	Caudal Regression Syndrome Caudal Regression Sequence Sacral Agenesis Caudal Dysgenesis Syndrome SDAM Caudal Dysplasia Sequence Caudal Dysplasia Sacral Agenesis Syndrome Sacral Regression Syndrome Sacral Defect And Anterior Sacral Meningocele Rudd Klimek Syndrome Sirenomelia
Ciliary Dyskinesia, Primary, 19	Primary Ciliary Dyskinesia 19 CILD19 Primary Ciliary Dyskinesia 19 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 19, With Or Without Situs Inversus Ics19 Immotile Cilia Syndrome 19 Dyskinesia, Ciliary, Primary, 19
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06477	HTR5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06478	Htr5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06479	Htr5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTR5A	MGD	MGI:96283
Canis familiaris	HTR5A	VGNC	VGNC:41832
Bos taurus	HTR5A	VGNC	VGNC:30001
Macaca mulatta	HTR5A	VGNC	VGNC:73545
Felis catus	HTR5A	VGNC	VGNC:102598
Rattus norvegicus	HTR5A	RGD	RGD:2851
Others	HTR5A	NCBI