DUSP13 - dual specificity phosphatase 13 Gene

Also Known as BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51207

About DUSP13

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,094,434-75,109,191 (from NCBI)

This gene has 15 transcripts (splice variants), 242 orthologues and 30 paralogues. Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues.

Summary

Members of the protein-tyrosine Phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

DUSP13 Products (8)

mRNA Protein Name
NM_001007271.2 NP_001007272.1 dual specificity protein phosphatase 13 isoform 1
NM_001007272.2 NP_001007273.1 dual specificity protein phosphatase 13 isoform 2
NM_001007273.2 NP_001007274.1 dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320842.2 NP_001307771.1 dual specificity protein phosphatase 13 isoform 3 precursor
NM_001320843.2 NP_001307772.1 dual specificity protein phosphatase 13 isoform 6
NM_001363514.2 NP_001350443.1 dual specificity protein phosphatase 13 isoform 9
NM_001412227.1 NP_001399156.1 dual specificity protein phosphatase 13 isoform 10
NM_016364.3 NP_057448.3 dual specificity protein phosphatase 13 isoform 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatase activity IDA
IDA: Inferred from direct assay
24531476 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
24531476 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP13 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (45 - 180)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 13

  • Testis- and skeletal muscle-specific DUSP

DUSP13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
DUSP13B Q9UII6 SH2B2 Homo sapiens O14492-2
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 SH2B2 Homo sapiens O14492-2
Y2H Array
32296183
Intra
DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Array
32296183
Intra
DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Prey Pooling
25416956
Intra
DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 LMNA Homo sapiens P02545
Y2H Array
31515488
Intra
DUSP13B Q9UII6 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
DUSP13B Q9UII6 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
DUSP13B Q9UII6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
DUSP13B Q9UII6 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
32296183
Intra
DUSP13B Q9UII6 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
25416956
Intra
DUSP13B Q9UII6 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
Intra
DUSP13B Q9UII6 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
DUSP13B Q9UII6 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myoclonic Epilepsy Of Lafora

  • Lafora Disease

  • Epilepsy, Progressive Myoclonic 2b

  • EPM2

  • Melf

  • Epilepsy, Progressive Myoclonic 2a

  • Epm2a

  • Lafora'S Disease

  • Lafora Body Disease

  • Lbd

  • Epilepsy, Progressive Myoclonic, 2a

  • Lafora Progressive Myoclonic Epilepsy

  • Epilepsy Progressive Myoclonic 2

  • Lafora Body Disorder

  • Pme Type 2

  • Progressive Myoclonic Epilepsy Type 2

  • Progressive Myoclonus Epilepsy Type 2

  • Epilepsy, Progressive Myoclonic 2

  • Epm2b

  • Ld

  • Progressive Myoclonic Epilepsy 2

  • Progressive Myoclonic Epilepsy 2a

  • Progressive Myoclonic Epilepsy 2b

  • Progressive Myoclonic Epilepsy Lafora Type

  • Epilepsy, Myoclonic, Of Lafora
Juvenile Polyposis Syndrome

  • JPS

  • Juvenile Intestinal Polyposis

  • Jip

  • Pji

  • Juvenile Gastrointestinal Polyposis

  • Juvenile Polyposis

  • Polyposis, Juvenile Intestinal

  • Polyposis, Familial, Of Entire Gastrointestinal Tract

  • Polyposis Familial Of Entire Gastrointestinal Tract

  • Polyposis Juvenile Intestinal

  • Polyposis Syndrome, Juvenile
Dystonia 3, Torsion, X-Linked

  • X-Linked Dystonia-Parkinsonism

  • DYT3

  • Xdp

  • Lubag

  • Dystonia-Parkinsonism, X-Linked

  • Torsion Dystonia-Parkinsonism, Filipino Type

  • Dyt-Taf1

  • X-Linked Dystonia-Parkinsonism Syndrome

  • X-Linked Torsion Dystonia-Parkinsonism Syndrome

  • Dystonia Musculorum Deformans

  • X-Linked Dystonia-Parkinsonism/Lubag

  • Lubag Syndrome

  • Dystonia-3

  • Torsion Dystonia-Parkinsonism Filipino Type

  • X-Linked Torsion Dystonia 3

  • Dystonia, Torsion, X-Linked, Type 3
Bruxism

  • Sleep Bruxism

  • Sleep-Related Bruxism

  • Bruxism - Teeth Grinding

  • Grinding Teeth

  • Sleep Related Bruxism

  • Teeth Grinding

  • Sleep Related Teeth Grinding
Myopathy

  • Muscular Diseases

  • Myopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04054 DUSP13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DUSP13 RGD RGD:1359712
Mus musculus DUSP13 MGD MGI:1351599
Bos taurus DUSP13 VGNC VGNC:107306
Canis familiaris DUSP13 VGNC VGNC:106597
Others DUSP13 NCBI