Melineurine
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC50 of 95.3 μM against AChE and an IC50 of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 85802-28-4
- Formula: C17H17NO3
- Molecular Weight:283.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Melineurine (100 μg/mL) inhibits electric eel acetylcholinesterase with an IC50 of 95.3 μM, with steric hindrance from its 3,3-dimethyl-2-propeneyloxyl substituent reducing its binding affinity compared to more potent acetylcholinesterase inhibitors[1].
Melineurine (0.1-1.0 μM, 100 μg/mL) inhibits horse serum butyrylcholinesterase with an IC50 of 28.0 μM via a mixed competitive mechanism, with strong binding affinity mediated by multiple hydrogen bonds and hydrophobic interactions with key active site residues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 85802-28-4
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Molecular Weight 283.32
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Formula C17H17NO3
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SMILES
COC1=C2C=COC2=NC3=C1C=CC(OC/C=C(C)/C)=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melineurine Related Classifications
HY-N17394 Related Classifications
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