PPIL2 - peptidylprolyl isomerase like 2 Gene

Also Known as CYC4; CYP60; UBOX7; Cyp-60; hCyP-60

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23759

About PPIL2

Cytogenetic location: 22q11.21-q11.22 Genomic coordinates (GRCh38): 22:21,666,012-21,700,015 (from NCBI)

This gene has 46 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 15.3), lymph node (RPKM 12.4) and 25 other tissues.

Summary

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

PPIL2 Products (4)

mRNA	Protein	Name
NM_001317996.2	NP_001304925.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_014337.4	NP_055152.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148175.3	NP_680480.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148176.3	NP_680481.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	20676357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15946952	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11435423	GOA
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	11435423	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	15946952	GOA
acts upstream of or within protein polyubiquitination	IDA IDA: Inferred from direct assay	11435423	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15946952	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11435423	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15946952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL2 Protein Structure

Rtf2

Pro_isomerase

0
100
200
300
400
520 a.a.

Protein Preferred Names	Protein Names
RING-type E3 ubiquitin-protein ligase PPIL2	PPIase

PPIL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPIL2	Q13356	ZNF830	Homo sapiens	Q96NB3	Y2H	22365833
Intra	PPIL2	Q13356	ZNF830	Homo sapiens	Q96NB3	Anti Tag CoIP	33961781
Intra	PPIL2	Q13356	DCAF10	Homo sapiens	Q5QP82	Anti Tag CoIP	33961781
Intra	PPIL2	Q13356	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	PPIL2	Q13356	TRIM23	Homo sapiens	P36406	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77151	PPIL2 Protein, Human (His)	Q13356-2 (G280-P457)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hawkinsinuria	4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency 4-Hppd Deficiency 4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency HWKS HAWK
Angiostrongyliasis	A. Cantonensis Angiostrongyliasis
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10955	PPIL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20085	Ppil2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26588	Ppil2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPIL2	RGD	RGD:1309484
Canis familiaris	PPIL2	VGNC	VGNC:44856
Felis catus	PPIL2	VGNC	VGNC:68989
Macaca mulatta	PPIL2	VGNC	VGNC:76239
Bos taurus	PPIL2	VGNC	VGNC:33202
Mus musculus	PPIL2	MGD	MGI:2447857
Others	PPIL2	NCBI