PPIL2 - peptidylprolyl isomerase like 2 Gene

Homo sapiens

Also known as CYC4; CYP60; UBOX7; Cyp-60; hCyP-60

Gene ID: 23759 | Gene type: protein coding

About PPIL2

Cytogenetic location: 22q11.21-q11.22 Genomic coordinates (GRCh38): 22:21,666,012-21,700,015 (from NCBI)

This gene has 46 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in thyroid (RPKM 15.3), lymph node (RPKM 12.4) and 25 other tissues.

Summary

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

PPIL2 Products(4)

mRNA	Protein	Name
NM_001317996.2	NP_001304925.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_014337.4	NP_055152.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148175.3	NP_680480.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform a
NM_148176.3	NP_680481.1	RING-type E3 ubiquitin-protein ligase PPIL2 isoform b

PPIL2 Protein Structure

Rtf2

Pro_isomerase

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

RING-type E3 ubiquitin-protein ligase PPIL2

PPIase

Recombinant PPIL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77151	PPIL2 Protein, Human (His)	Q13356-2 (G280-P457)	≥95%

Related Diseases

Diseases

Alias

Hawkinsinuria

4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency	4-Hppd Deficiency
4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency	HWKS
HAWK

Angiostrongyliasis

A. Cantonensis Angiostrongyliasis

Kidney Rhabdoid Cancer

Rhabdoid Tumor Of The Kidney	Kidney Rhabdoid Tumor
Renal Rhabdoid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10955	PPIL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPIL2	RGD	RGD:1309484
Canis familiaris	PPIL2	VGNC	VGNC:44856
Felis catus	PPIL2	VGNC	VGNC:68989
Macaca mulatta	PPIL2	VGNC	VGNC:76239
Bos taurus	PPIL2	VGNC	VGNC:33202
Mus musculus	PPIL2	MGD	MGI:2447857
Others	PPIL2	NCBI

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