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製品番号: HY-12114

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Serlopitant

Name: Serlopitant
Brand: MedChemExpress
SKU: HY-12114
Availability: PreOrder

(別名: VPD-737; MK-0594)

Serlopitant (VPD-737) is an orally active Neurokinin 1 receptor antagonist. Serlopitant inhibits pruritus signal transduction via NK receptors in spinal neurons and brain regions, and blocks the efferent function of substance P in the skin. Serlopitant can be used in research related to chronic pruritus, prurigo nodularis, and pruritus associated with psoriasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 860642-69-9
分子式: C₂₉H₂₈F₇NO₂
分子量:555.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Serlopitant 構造式

CAS 番号: 860642-69-9

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 臨床実験
化学情報
プロトコル (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

NK1R

Neurokinin Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.06 nM Compound: 17	Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin	[PMID: 19354254]
CHO	IC₅₀	0.06 nM Compound: 2	Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells	[PMID: 23808489]
CHO	IC₅₀	9.5 nM Compound: 17	Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin	[PMID: 19354254]
CHO	IC₅₀	9.5 nM Compound: 2	Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum	[PMID: 23808489]

体外実験

Serlopitant induces a dose-dependent reduction in chronic pruritus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 860642-69-9
分子量 555.53
分子式 C₂₉H₂₈F₇NO₂
SMILES

O=C1C=C(N2C[C@@]3([H])CC[C@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)[C@@H](C5=CC=C(F)C=C5)[C@]3([H])C2)CC1
別名

VPD-737; MK-0594
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Animals and Diseases

Imiquimod-Induced Psoriasiform Dermatitis
Imiquimod (IMQ)-induced psoriasiform dermatitis is a widely used murine model in which topical application of IMQ, a Toll-like receptor 7 (TLR7) agonist, triggers innate immune activation in the skin and induces a psoriasis-like inflammatory cascade characterized by epidermal hyperplasia, immune cell infiltration, and cytokine production dominated by the IL-23/IL-17 axis. This inflammatory response is mediated through activation of dendritic cells and downstream induction of IL-23, IL-17A, IL-22, and related pro-inflammatory mediators, recapitulating key features of human plaque psoriasis and enabling mechanistic and therapeutic studies. The model is commonly induced using Aldara (5% IMQ cream) applied topically to murine skin, resulting in rapid onset of erythema, scaling, and thickening that can be quantified as disease severity indices and validated histologically.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yosipovitch G, et al. Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial. J Am Acad Dermatol. 2018 May;78(5):882-891.e10. [Content Brief]

[2]. Ständer S, et al. The NK1 receptor antagonist serlopitant for treatment of chronic pruritus. Expert opinion on investigational drugs. 2019 Aug;28(8):659-666.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 臨床実験
化学情報
プロトコル
純度とドキュメンテーション
参考文献

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Serlopitant

Neurokinin Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

Cellular Effect

体外実験

臨床実験

化学情報

プロトコル

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Serlopitant

Neurokinin Receptor アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

臨床実験

化学情報

プロトコル

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Serlopitant 関連分類

HY-12114 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target