860642-69-9
Chemical Structure
Serlopitant
Synonym(s): VPD-737; MK-0594
- CAS No.: 860642-69-9
- Formula:C29H28F7NO2
- Molecular Weight:555.53
IUPAC Name: 3-((3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl)cyclopent-2-en-1-one
InChIKey: FLNYCRJBCNNHRH-OIYLJQICSA-N
SMILES: O=C1C=C(N2C[C@@]3([H])CC[C@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)[C@@H](C5=CC=C(F)C=C5)[C@]3([H])C2)CC1
Biological Activity: Serlopitant (VPD-737) is an orally active Neurokinin 1 receptor antagonist. Serlopitant inhibits pruritus signal transduction via NK receptors in spinal neurons and brain regions, and blocks the efferent function of substance P in the skin. Serlopitant can be used in research related to chronic pruritus, prurigo nodularis, and pruritus associated with psoriasis[1][2].
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Serlopitant | Serlopitant (VPD-737) is an orally active Neurokinin 1 receptor antagonist. Serlopitant inhibits pruritus signal transduction via NK receptors in spinal neurons and brain regions, and blocks the efferent function of substance P in the skin. Serlopitant can be used in research related to chronic pruritus, prurigo nodularis, and pruritus associated with psoriasis. | |||||||||||||||||||||
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References
- [1]. Yosipovitch G, et al. Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial. J Am Acad Dermatol. 2018 May;78(5):882-891.e10. [Content Brief]
- [2]. Ständer S, et al. The NK1 receptor antagonist serlopitant for treatment of chronic pruritus. Expert opinion on investigational drugs. 2019 Aug;28(8):659-666.
