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製品番号: HY-N21828

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Annonin VI

Annonin VI is an inhibitor of NADH:ubiquinone oxidoreductase (complex I; complex I) and glucose:ubiquinone oxidoreductase discovered in the seeds of Annona squamosa. Annonin VI exhibits an IC₅₀ of 0.02 nmol/mg protein against bovine heart complex I, and an IC₅₀ of 12.4 nmol/mg protein against glucose dehydrogenase (GDH) derived from Gluconobacter oxydans. Annonin VI acts in a partially competitive manner on the region associated with the ubiquinone catalytic site of complex I, blocking electron transfer from high-potential iron-sulfur clusters to ubiquinone. Annonin VI binds competitively with ubiquinone at the homologous ubiquinone site on GDH. Annonin VI can be used in the research of bacterial infections, insecticides, and cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 129212-94-8
分子式: C₃₇H₆₆O₇
分子量:622.92

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Annonin VI 構造式

CAS 番号: 129212-94-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Annonin VI (1 min) potently inhibits NADH:ubiquinone oxidoreductase (complex I) from bovine heart (IC₅₀ 0.02 nmol/mg protein), the corresponding enzyme from Escherichia coli (IC₅₀ 0.02 nmol/mg protein), and the corresponding enzyme from Neurospora crassa (IC₅₀ 0.2 nmol/mg protein), and simultaneously inhibits glucose:ubiquinone oxidoreductase from Gluconobacter oxidans (IC₅₀ 12.4 nmol/mg protein)^[2].
Annonin VI (0-10 nM) inhibits bovine heart NADH:ubiquinone oxidoreductase in a partially competitive manner and inhibits glucose:ubiquinone oxidoreductase from Gluconobacter oxidans in a competitive manner, with both inhibitory effects targeting ubiquinone-2^[2].
Annonin VI (compound 2) is an acetogenin derived from the seeds of Annona squamosa, and its structure consists of a hydroxylated bis-tetrahydrofuran core and an α,β-unsaturated-γ-lactone moiety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 129212-94-8
分子量 622.92
分子式 C₃₇H₆₆O₇
SMILES

O=C1C(CC(O)CCCCCCCCCC[C@H]([C@]2([H])O[C@@H]([C@@H]3O[C@@](CC3)([H])[C@@H](O)CCCCCCCCCC)CC2)O)=C[C@H](C)O1
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Nonfon M, et al. Four annonins from Annona squamosa[J]. Phytochemistry, 1990, 29(6): 1951-1954.

[2]. Friedrich T, et al. Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. Eur J Biochem. 1994 Jan 15;219(1-2):691-8.

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100 mg

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