Deoxymikanolide
Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 23753-57-3
- 分子式: C15H16O5
- 分子量:276.28
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Deoxymikanolide (15.625-125 mg/L; measured at 2-hour intervals) inhibits the growth of Ralstonia solanacearum race #4 in a concentration-dependent manner, with complete suppression at higher concentrations[1].
Deoxymikanolide (125 mg/L; 2-24 h) induces time-dependent ultrastructural damage to Ralstonia solanacearum race #4, including cell shrinkage, cytoplasmic leakage, and abnormal cell shapes, with complete cytoderm thickening at 24 h[1].
Deoxymikanolide (62.5-125 mg/L; measured every 2 h for 24 h) significantly increases the phosphorus utilization ratio of Ralstonia solanacearum race #4[1].
Deoxymikanolide (62.5-125 mg/L; measured at 5-hour intervals) inhibits the activities of CAT, POD, and SOD in Ralstonia solanacearum race #4, with SOD inhibition rates of 73.50% (62.5 mg/l) and 86.41% (125 mg/L) at 10 min[1].
Deoxymikanolide (62.5-125 mg/L; 24 h) induces significant intracellular ROS accumulation in Ralstonia solanacearum race #4, exceeding levels induced by 340 mg/l H2O2[1].
Deoxymikanolide (62.5-125 mg/L; 24 h post-treatment) increases MDA levels in Ralstonia solanacearum race #4 at 24 h, indicating lipid peroxidation from excessive ROS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (male, 20-25 g)[2]
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Dosage:10 mg/kg
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Administration:p.o.
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Result:Reduced acetic acid-induced writhing to 8.5 and produced a 67.3% inhibition of writhing compared to the control group (26.0 writhings).
化学情報
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CAS 番号 23753-57-3
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分子量 276.28
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分子式 C15H16O5
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SMILES
C=C1[C@]2([H])[C@](OC1=O)([H])C[C@]3([C@@](CCC4=C[C@@]2([H])OC4=O)([H])O3)C
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Deoxymikanolide 関連分類
HY-N13756 関連分類
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Keywords
- Deoxymikanolide
- 23753-57-3
- Bacterial
- Reactive Oxygen Species (ROS)
- SOD
- ROS
- mice
- electric conductivity
- MDA
- peroxidase
- CAT
- superoxide dismutase
- phosphorus metabolism
- malondialdehyde
- bacterial wilt
- Mikania micrantha Bunge
- male Swiss mice
- glycan metabolism
- Ralstonia solanacearum race #4
- catalase
- Ralstonia solanacearum
- POD
- intrabacterial reactive oxygen species
- Inhibitor
- inhibitor
- inhibit