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RMDN3 - regulator of microtubule dynamics 3 Gene

Also Known as RMD3; RMD-3; FAM82C; FAM82A2; ptpip51

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55177

About RMDN3

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,735,887-40,755,254 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 16.9), lung (RPKM 14.6) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in cellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

RMDN3 Products (6)

mRNA	Protein	Name
NM_001304802.2	NP_001291731.1	regulator of microtubule dynamics protein 3 isoform 1
NM_001323894.2	NP_001310823.1	regulator of microtubule dynamics protein 3 isoform 1
NM_001323895.2	NP_001310824.1	regulator of microtubule dynamics protein 3 isoform 2
NM_001323896.2	NP_001310825.1	regulator of microtubule dynamics protein 3 isoform 3
NM_001323897.2	NP_001310826.1	regulator of microtubule dynamics protein 3 isoform 3
NM_018145.3	NP_060615.1	regulator of microtubule dynamics protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables microtubule binding	IDA IDA: Inferred from direct assay	18070910	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18771726	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	22131369	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	22131369	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	29858488	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	18070910	GOA
located in organelle membrane contact site	IDA IDA: Inferred from direct assay	29858488	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	18070910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
regulator of microtubule dynamics protein 3	TCPTP-interacting protein 51

RMDN3 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RMDN3	Q96TC7	VAPA	Homo sapiens	Q9P0L0	Y2H	21900206
Intra	RMDN3	Q96TC7	TMEM243	Homo sapiens	Q9BU79	Validated Y2H	32296183
Intra	RMDN3	Q96TC7	MOSPD2	Homo sapiens	Q8NHP6	Confocal	29858488
Intra	RMDN3	Q96TC7	MOSPD2	Homo sapiens	Q8NHP6	Anti Tag CoIP	29858488
Intra	RMDN3	Q96TC7	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	RMDN3	Q96TC7	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	RMDN3	Q96TC7	YWHAB	Homo sapiens	P31946	CoIP	15324660
Intra	RMDN3	Q96TC7	YWHAB	Homo sapiens	P31946	PLA	21972092
Intra	RMDN3	Q96TC7	YWHAB	Homo sapiens	P31946	Pull Down	18771726
Intra	RMDN3	Q96TC7	PELI2	Homo sapiens	Q9HAT8	Validated Y2H	32296183
Intra	RMDN3	Q96TC7	VKORC1	Homo sapiens	Q9BQB6	Validated Y2H	32296183
Intra	RMDN3	Q96TC7	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Amyotrophic Lateral Sclerosis 8	Amyotrophic Lateral Sclerosis Type 8 ALS8 Sclerosis, Lateral, Amyotrophic, Type Type 8
Amyotrophic Lateral Sclerosis 16, Juvenile	Amyotrophic Lateral Sclerosis Type 16 ALS16 Amyotrophic Lateral Sclerosis 16 Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Alzheimer Disease 7	Ad7 Alzheimer'S Disease 7 Alzheimer Disease, Familial, 7 Alzheimer Disease-7 Alzheimer Disease, Familial 7
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12013	RMDN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22777	Rmdn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	RMDN3	VGNC	VGNC:64651
Macaca mulatta	RMDN3	VGNC	VGNC:76821
Rattus norvegicus	RMDN3	RGD	RGD:1308697
Bos taurus	RMDN3	VGNC	VGNC:33993
Mus musculus	RMDN3	MGD	MGI:1915059
Canis familiaris	RMDN3	VGNC	VGNC:45607
Others	RMDN3	NCBI