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United States

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製品番号: HY-189248

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HK262

HK262 is a METTL21A inhibitor, with an IC₅₀ of 1.10 μM against human METTL21A. HK262 reduces the enzymatic activity of the protein lysine methyltransferase METTL21A. HK262 can be used in studies of hepatocellular carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₆H₁₅F₅N₆O₄S
分子量:482.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

HK262 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

METTL21A

1.10 μM (IC₅₀)

Histone Methyltransferase アイソフォーム固有の製品をすべて表示 :

体外実験

HK262 (compound 6n) is the most potent METTL21A inhibitor identified in this series, with an IC₅₀ of 1.10 μM for the purified recombinant human METTL21A enzyme^[1].
HK262 (100 μM; 2 h) displays favorable kinetic solubility of 85 μM in pH 7.4 phosphate-buffered saline^[1].
HK262 (120 min) exhibits high stability in both human and mouse plasma following 120 min of incubation^[1].
HK262 (45 min) displays high metabolic stability in vitro in both human liver microsomes and mouse liver microsomes after 45 min of incubation^[1].
HK262 (50 μM; 60 min) achieves high intracellular accumulation of ¹⁸24 μM in HepG2 cells following 60 min of exposure to an initial 50 μM extracellular concentration^[1].
HK262 (10 μM; 72 h) does not reduce the viability of HepG2 cells after 72 h of exposure at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HepG2 cells
Concentration:

10 μM
Incubation Time:

72 h
Result:

Resulted in HepG2 cell viability of 102% of the untreated control value after 72 h of exposure, with no observable reduction in cell viability.

化学情報

分子量 482.39
分子式 C₁₆H₁₅F₅N₆O₄S
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C23)O[C@@H]1C(NC4=CC=C(S(F)(F)(F)(F)F)C=C4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kocek H, et al. First-in-class inhibitors of the protein lysine methyltransferase METTL21A. European journal of medicinal chemistry. 2026 Aug 11;319:119227.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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HK262

Histone Methyltransferase アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

体外実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HK262 関連分類

HY-189248 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target