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United States

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製品番号: HY-N17394

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Melineurine

Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 85802-28-4
分子式: C₁₇H₁₇NO₃
分子量:283.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Melineurine 構造式

CAS 番号: 85802-28-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

体外実験

Melineurine (100 μg/mL) inhibits electric eel acetylcholinesterase with an IC₅₀ of 95.3 μM, with steric hindrance from its 3,3-dimethyl-2-propeneyloxyl substituent reducing its binding affinity compared to more potent acetylcholinesterase inhibitors^[1].
Melineurine (0.1-1.0 μM, 100 μg/mL) inhibits horse serum butyrylcholinesterase with an IC₅₀ of 28.0 μM via a mixed competitive mechanism, with strong binding affinity mediated by multiple hydrogen bonds and hydrophobic interactions with key active site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 85802-28-4
分子量 283.32
分子式 C₁₇H₁₇NO₃
SMILES

COC1=C2C=COC2=NC3=C1C=CC(OC/C=C(C)/C)=C3
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sichaem J, et al. Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015;10(8):1359-1362. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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