製品番号: HY-N2123

Neoliquiritin

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.85%
CAS 番号: 5088-75-5
分子式: C₂₁H₂₂O₉
分子量:418.39

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Neoliquiritin 構造式

CAS 番号: 5088-75-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Caspase 3

Caspase-7

Caspase アイソフォーム固有の製品をすべて表示 :

体外実験

Neoliquiritin (48 h after 48 h initial cell seeding) shows moderate, cell-dependent cytotoxicity against HSC-2, HSC-3, HSC-4, HL-60 tumor cells and HGF, HPC, HPLF normal cells, with a tumor-specificity index of 0.264^[2].
Neoliquiritin (2.5-10 µg/mL; 24 h) significantly increases the viability of SH-SY5Y cells^[3].
Neoliquiritin (2.5-10 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP⁺) significantly protects SH-SY5Y cells from MPP⁺-induced neurotoxicity, restoring cell viability to ~80% of control^[3].
Neoliquiritin (2.5 µg/mL; 2 h pre-treatment, followed by 24 h incubation with MPP⁺) significantly attenuates MPP⁺-induced elevation of caspase 3/7 activity in SH-SY5Y cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells
Concentration:

2.5 µg/mL; 5 µg/mL; 10 µg/mL
Incubation Time:

24 h
Result:

Increased cell viability significantly relative to control at 2.5 µg/mL.
Increased cell viability significantly relative to control at 5 µg/mL.
Increased cell viability significantly relative to control at 10 µg/mL.

Cell Cytotoxicity Assay^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells exposed to MPP+
Concentration:

2.5 µg/mL; 5 µg/mL; 10 µg/mL
Incubation Time:

2 h pre-treatment, followed by 24 h incubation with MPP+
Result:

Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 2.5 µg/mL.
Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 5 µg/mL.
Restored cell viability to ~80% of control relative to MPP⁺-treated cells at 10 µg/mL.

Apoptosis Analysis^[3]

Cell Line:

human neuroblastoma SH-SY5Y cells exposed to MPP+
Concentration:

2.5 µg/mL
Incubation Time:

2 h pre-treatment, followed by 24 h incubation with MPP+
Result:

Reduced caspase 3/7 activity to ~1.5-fold of control relative to MPP+-treated cells.

体内実験

Licorice total flavonoids (LTF; containing 15.74% Neoliquiritin) (87.5-350 mg/kg; p.o.; daily; for 4 weeks) dose-dependently reduce MDA, cholesterol, TG levels and hepatic fat vacuole area in the liver of NAFLD mice, and improve the hepatic antioxidant status of mice with alcoholic liver disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice with Non-alcoholic fatty liver disease (male, 8 weeks old, 20 g)^[1]
Dosage:

87.5 mg/kg; 175 mg/kg; 350 mg/kg
Administration:

p.o.; daily; 4 weeks
Result:

Reduced hepatic TG to 166.22 μmol/g, and reduced relative area of hepatic fat vacuoles by 73.68% at 87.5 mg/kg.
Reduced hepatic MDA to 2.12 nmol/g, hepatic cholesterol to 0.100 mmol/g, hepatic TG to 147.33 μmol/g, and reduced relative area of hepatic fat vacuoles by 79.53% at 175 mg/kg.
Reduced hepatic MDA to 1.99 nmol/g, hepatic cholesterol to 0.096 mmol/g, hepatic TG to 128.45 μmol/g, and reduced relative area of hepatic fat vacuoles by 85.14% at 350 mg/kg.

化学情報

CAS 番号 5088-75-5
性状 Solid
分子量 418.39
分子式 C₂₁H₂₂O₉
Color White to yellow
SMILES

O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C13
Structure Classification
- Flavonoids
- Flavonones
- Phenols
- Monophenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

All

Sort by:

Journal Impact Factor

Bioorg Med Chem

Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]

2025 Sep 27:131:118423. PMID: 41033076

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (597.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3901 mL

11.9506 mL

23.9011 mL

5 mM

0.4780 mL

2.3901 mL

4.7802 mL

10 mM

0.2390 mL

1.1951 mL

2.3901 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gou S, et al. Hepatoprotective effect of total flavonoids from Glycyrrhiza uralensis Fisch in liver injury mice[J]. Natural product research, 2021, 35(24): 6083-6087.

[2]. Ohno H, et al. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res. 2013;33(8):3061-3068. [Content Brief]

[3]. Eltahir A O E, et al. Neuroprotective effects of Glycyrrhiza glabra total extract and isolated compounds[J]. Pharmaceuticals, 2024, 17(7): 852.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3901 mL	11.9506 mL	23.9011 mL	59.7529 mL
	5 mM	0.4780 mL	2.3901 mL	4.7802 mL	11.9506 mL
	10 mM	0.2390 mL	1.1951 mL	2.3901 mL	5.9753 mL
	15 mM	0.1593 mL	0.7967 mL	1.5934 mL	3.9835 mL
	20 mM	0.1195 mL	0.5975 mL	1.1951 mL	2.9876 mL
	25 mM	0.0956 mL	0.4780 mL	0.9560 mL	2.3901 mL
	30 mM	0.0797 mL	0.3984 mL	0.7967 mL	1.9918 mL
	40 mM	0.0598 mL	0.2988 mL	0.5975 mL	1.4938 mL
	50 mM	0.0478 mL	0.2390 mL	0.4780 mL	1.1951 mL
	60 mM	0.0398 mL	0.1992 mL	0.3984 mL	0.9959 mL
	80 mM	0.0299 mL	0.1494 mL	0.2988 mL	0.7469 mL
	100 mM	0.0239 mL	0.1195 mL	0.2390 mL	0.5975 mL

Keywords

Neoliquiritin

1 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Neoliquiritin

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Natural Product Library

Anti-Cancer Compound Library

Glycoside Compound Library

Lipid Compound Library

Medicine Food Homology Compound Library

Phenols Library

Pyroptosis Compound Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Protease Inhibitor Library

Highly Selective Inhibitors Library

Multi-Target Compound Library

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Tonifying Traditional Chinese Medicine Monomer Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Neoliquiritin

Caspase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Neoliquiritin 関連分類

HY-N2123 関連分類