NOS-IN-3
NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 μM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the research of inducible isoform involved diseases, such as septic shock.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2761725-68-0
- 分子式: C10H15N3O
- 分子量:193.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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iNOS |
nNOS |
体外実験
NOS-IN-3 (Compound 9a) shows high iNOS selectivity without eNOS inhibition activity [1].
NOS-IN-3 (0-100 µM, 30 min) has little toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HUVECs
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Concentration:10, 20, 50, 100, 500 µM
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Incubation Time:30 min
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Result:Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
化学情報
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CAS 番号 2761725-68-0
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分子量 193.25
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分子式 C10H15N3O
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SMILES
CC(NCCC(C1=CC=CN=C1)O)=N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NOS-IN-3 関連分類
HY-115917 関連分類
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