PD-159206
PD-159206 is an anti-HIV agent. PD-159206 inhibits early pre-integration steps of the HIV life cycle, and delays sequential progression of reverse transcription products. PD-159206 can be used for the research of HIV infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 171744-42-6
- 分子式: C26H32N2O6S2
- 分子量:532.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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HIV-1 |
体外実験
PD-159206 (5 days) inhibits replication of laboratory and clinical HIV-1 isolates, HIV-2, and SIV in H9, MT4, CEM, CEM-SS, PBMC, and macrophage cell systems[1].
PD-159206 (0.1-100 μM; 48 h) dose-dependently inhibits HIV-1 replication in HeLa-CD4-LTR-β-gal cells[1].
PD-159206 (20 μM; 48 h) inhibits early steps of the HIV-1 life cycle in HeLa-CD4-LTR-β-gal cells, with maximum effectiveness when added within the first 4 hours of infection and complete loss of activity by 6 hours post-infection[1].
PD-159206 (20 μM; 4-24 h) delays the progression of HIV-1 reverse transcription and prevents formation of 2LTR circles in H9 cells, indicating inhibition of pre-integration steps in the viral life cycle[1].
PD-159206 (0.1-100 μM; 48 h) shows no cytotoxicity up to 100 μM in HeLa Magi cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HeLa Magi cells
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Concentration:0.1; 1; 3; 6; 12; 25; 50; 100 μM
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Incubation Time:48 h
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Result:Showed no cytotoxicity in HeLa Magi cells.
Remained cell viability above 80% at all tested concentration.
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Cell Line:H9 cells infected with HIV-III B
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Concentration:20 μM
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Incubation Time:4; 12; 24 h
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Result:Delayed the progression of HIV-1 reverse transcription and prevents formation of 2LTR circles in H9 cells.
化学情報
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CAS 番号 171744-42-6
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分子量 532.67
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分子式 C26H32N2O6S2
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SMILES
O=C(C(C(CC)C)NC(C1=C(SSC2=C(C(NC(C(CC)C)C(O)=O)=O)C=CC=C2)C=CC=C1)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
参考文献
[1]. Sharmeen L, et al. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001;49(2):101-114. [Content Brief]
[2]. Ye M, et al. Microdialysis sampling of the isothiazolone, PD-161374, and its thiol and disulfide metabolites. J Pharm Biomed Anal. 2000;24(2):273-280. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PD-159206 関連分類
HY-183663 関連分類
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