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製品番号: HY-106434

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Piritrexim

(別名: BW 301U; NSC 351521)

カスタマーレビュー

Based on 1 Customer Validation

Piritrexim (BW 301U) is a potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC₅₀ values of 0.038 and 0.011 μM, respectively. Piritrexim can be used for acquired immune deficiency syndrome (AIDS) research. Piritrexim also is an anticancer agent.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.07%
CAS 番号: 72732-56-0
分子式: C₁₇H₁₉N₅O₂
分子量:325.37

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Piritrexim 構造式

CAS 番号: 72732-56-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	24 nM Compound: PTX	Cytotoxic activity evaluated against A549 tumor cells Cytotoxic activity evaluated against A549 tumor cells	[PMID: 8632413]
CCRF S-180	ED₅₀	0.012 μM Compound: BW-301U	Cytotoxic activity against the S180 cell cultures Cytotoxic activity against the S180 cell cultures	[PMID: 6928967]
CCRF-CEM	IC₅₀	0.013 μM Compound: 5	Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture Concentration causing inhibition of CCRF-CEM human leukemic lymphoblasts growth in a 72 hr culture	[PMID: 15974594]
D54 cell line	IC₅₀	230 nM Compound: PTX	Cytotoxic Activity was evaluated against D54 tumor cells Cytotoxic Activity was evaluated against D54 tumor cells	[PMID: 8632413]
Daoy	IC₅₀	70 nM Compound: PTX	Cytotoxic activity was evaluated against Daoy tumor cells Cytotoxic activity was evaluated against Daoy tumor cells	[PMID: 8632413]
HCT-8	IC₅₀	68 nM Compound: PTX	Cytotoxic Activity was evaluated against HCT-8 tumor cells Cytotoxic Activity was evaluated against HCT-8 tumor cells	[PMID: 8632413]
L1210	ED₅₀	0.002 μM Compound: BW-301U	Cytotoxic activity against the L1210 cell cultures Cytotoxic activity against the L1210 cell cultures	[PMID: 6928967]
NCI-H460	IC₅₀	260 nM Compound: PTX	Cytotoxic Activity was evaluated against H460 tumor cells Cytotoxic Activity was evaluated against H460 tumor cells	[PMID: 8632413]
P388	IC₅₀	21 nM Compound: PTX	Cytotoxic activity was evaluated against P388D1 tumor cells Cytotoxic activity was evaluated against P388D1 tumor cells	[PMID: 8632413]
U-373MG ATCC	IC₅₀	55 nM Compound: PTX	Cytotoxic activity was evaluated against U373MG tumor cells Cytotoxic activity was evaluated against U373MG tumor cells	[PMID: 8632413]
U-87MG ATCC	IC₅₀	48 nM Compound: PTX	Cytotoxic activity was evaluated against U87MG tumor cells Cytotoxic activity was evaluated against U87MG tumor cells	[PMID: 8632413]
Vero	IC₅₀	30 nM Compound: PTX	Cytotoxic Activity was evaluated against Vero tumor cells Cytotoxic Activity was evaluated against Vero tumor cells	[PMID: 8632413]
W256	ED₅₀	0.008 μM Compound: BW-301U	Cytotoxic activity against the Walker 256 carcinosarcoma in rats Cytotoxic activity against the Walker 256 carcinosarcoma in rats	[PMID: 6928967]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 72732-56-0
性状 Solid
分子量 325.37
分子式 C₁₇H₁₉N₅O₂
Color Off-white to light yellow
SMILES

CC1=C(CC2=C(C=CC(OC)=C2)OC)C=NC3=NC(N)=NC(N)=C13
別名

BW 301U; NSC 351521
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Rosowsky A, et al. 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. J Med Chem. 1993 Oct 15;36(21):3103-12. [Content Brief]

[2]. Zink M, et al. Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling investigations. Eur J Med Chem. 2004 Dec;39(12):1079-88. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
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- 臨床実験
化学情報
純度とドキュメンテーション
参考文献

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Piritrexim

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Piritrexim

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Piritrexim 関連分類

HY-106434 関連分類