V-11-0711
Based on 1 Customer Validation
V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.00%
- CAS 番号: 1428339-47-2
- 分子式: C27H35NO3
- 分子量:421.57
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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CHKα1 |
Chk-α 20 nM (IC50) |
体外実験
V-11-0711 (0.1-10 μM, 48 h) reduces PC and GPC levels in MDA-MB-231 cells and SUM149 cells[2].
V-11-0711 (0.1-10 μM, 48 h) does not reduce Chk-α protein levels in SUM149 cells at low doses, but reduces Chk-α protein levels by approximately 50% at high doses[2].
V-11-0711 (0.1-10 μM, 48 h) significantly reduces the level of PtdCho in SUM149 cells, and increases fatty acid levels at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) increases the number of lipid droplets in SUM149 cells by approximately 1.8 times at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) induces apoptosis in SUM149 cells at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SUM149 cells, MDA-MB-231 cells
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Concentration:0.1 μM, 1 μM, 10 μM
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Incubation Time:48 h
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Result:Did not reduce Chk-α protein levels in SUM149 cells at low doses, but reduced Chk-α protein levels by approximately 50% at high doses.
In MDA-MB-231, Chk-α protein levels did not decrease; in fact, they showed a slight upward trend.
化学情報
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CAS 番号 1428339-47-2
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性状 Solid
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分子量 421.57
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分子式 C27H35NO3
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Color White to off-white
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SMILES
O[C@@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 10 mg/mL (23.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2(3):e38. [Content Brief]
[2]. Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3721 mL | 11.8604 mL | 23.7209 mL | 59.3021 mL |
| 5 mM | 0.4744 mL | 2.3721 mL | 4.7442 mL | 11.8604 mL | |
| 10 mM | 0.2372 mL | 1.1860 mL | 2.3721 mL | 5.9302 mL | |
| 15 mM | 0.1581 mL | 0.7907 mL | 1.5814 mL | 3.9535 mL | |
| 20 mM | 0.1186 mL | 0.5930 mL | 1.1860 mL | 2.9651 mL |
V-11-0711 関連分類
HY-120337 関連分類
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