V-11-0711 hydrochloride
V-11-0711 hydrochloride is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 hydrochloride can significantly reduce PCho levels. V-11-0711 hydrochloride causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 hydrochloride can be used for the study of cervical cancer and triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C27H36ClNO3
- Molecular Weight:458.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Chk-α 20 nM nM (IC50) |
V-11-0711 (0.1-10 μM, 48 h) hydrochloride reduces PC and GPC levels in MDA-MB-231 cells and SUM149 cells[2].
V-11-0711 (0.1-10 μM, 48 h) hydrochloride does not reduce Chk-α protein levels in SUM149 cells at low doses, but reduces Chk-α protein levels by approximately 50% at high doses[2].
V-11-0711 (0.1-10 μM, 48 h) hydrochloride significantly reduces the level of PtdCho in SUM149 cells, and increases fatty acid levels at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) hydrochloride increases the number of lipid droplets in SUM149 cells by approximately 1.8 times at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) hydrochloride induces apoptosis in SUM149 cells at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SUM149 cells, MDA-MB-231 cells
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Concentration:0.1 μM, 1 μM, 10 μM
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Incubation Time:48 h
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Result:Did not reduce Chk-α protein levels in SUM149 cells at low doses, but reduced Chk-α protein levels by approximately 50% at high doses.
In MDA-MB-231, Chk-α protein levels did not decrease; in fact, they showed a slight upward trend.
Chemical Information
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Molecular Weight 458.03
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Formula C27H36ClNO3
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SMILES
O[C@@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2(3):e38. [Content Brief]
[2]. Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
V-11-0711 hydrochloride Related Classifications
HY-120337A Related Classifications
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