V-11-0711
Based on 1 Customer Validation
V-11-0711 is a potent and selective Chk-α (IC50 = 20 nM) inhibitor. V-11-0711 can significantly reduce PCho levels. V-11-0711 causes a reversible growth arrest. V-11-0711 induces apoptosis at high concentrations. V-11-0711 can be used for the study of cervical cancer and triple-negative breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 1428339-47-2
- Formula: C27H35NO3
- Molecular Weight:421.57
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
CHKα1 |
Chk-α 20 nM (IC50) |
V-11-0711 (0.1-10 μM, 48 h) reduces PC and GPC levels in MDA-MB-231 cells and SUM149 cells[2].
V-11-0711 (0.1-10 μM, 48 h) does not reduce Chk-α protein levels in SUM149 cells at low doses, but reduces Chk-α protein levels by approximately 50% at high doses[2].
V-11-0711 (0.1-10 μM, 48 h) significantly reduces the level of PtdCho in SUM149 cells, and increases fatty acid levels at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) increases the number of lipid droplets in SUM149 cells by approximately 1.8 times at 10 μM[2].
V-11-0711 (0.1-10 μM, 48 h) induces apoptosis in SUM149 cells at 10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SUM149 cells, MDA-MB-231 cells
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Concentration:0.1 μM, 1 μM, 10 μM
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Incubation Time:48 h
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Result:Did not reduce Chk-α protein levels in SUM149 cells at low doses, but reduced Chk-α protein levels by approximately 50% at high doses.
In MDA-MB-231, Chk-α protein levels did not decrease; in fact, they showed a slight upward trend.
Chemical Information
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CAS No. 1428339-47-2
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Appearance Solid
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Molecular Weight 421.57
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Formula C27H35NO3
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Color White to off-white
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SMILES
O[C@@]([C@]1([H])C2CCN(CC2)C1)(C3=CC=CC=C3)CCC4=C(C=CC=C4)OC5CCOCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (23.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Falcon SC, et al. A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival. Oncogenesis. 2013;2(3):e38. [Content Brief]
[2]. Mori N, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3721 mL | 11.8604 mL | 23.7209 mL | 59.3021 mL |
| 5 mM | 0.4744 mL | 2.3721 mL | 4.7442 mL | 11.8604 mL | |
| 10 mM | 0.2372 mL | 1.1860 mL | 2.3721 mL | 5.9302 mL | |
| 15 mM | 0.1581 mL | 0.7907 mL | 1.5814 mL | 3.9535 mL | |
| 20 mM | 0.1186 mL | 0.5930 mL | 1.1860 mL | 2.9651 mL |
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