Sodium tauroglycocholate
Based on 1 Customer Validation
Sodium tauroglycocholate (Tauroglycocholic acid sodium salt) is a multifunctional surfactant and penetration enhancer that can serve as a cholegraphic contrast agent. In organic solvents, Sodium tauroglycocholate embeds and stabilizes invertase by forming reverse micelles, and prolongs its active lifespan. In terms of transdermal absorption, Sodium tauroglycocholate effectively regulates the flux of aminophylline through snake slough by binding to keratin filaments, disrupting keratinocytes and altering lipid components of the stratum corneum. It exhibits rapid penetration characteristics without lag time at a concentration of 100 μg/mL. Sodium tauroglycocholate does not interfere with the hepatic uptake of Gd-EOB-DTPA by the bile acid transport system in rat hepatocytes.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 41945-48-6
- Formula: C28H47N2NaO8S
- Molecular Weight:594.74
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sodium tauroglycocholate (100-500 μg/mL; 24 h) significantly enhances aminophylline transdermal permeation through shed Vipera labatina snake skin in a concentration-dependent (decreasing) manner, with the 100 μg/mL concentration yielding the highest enhancement factor of 6.42[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar-Han Rat (male, 200-260 g, Schering SPF)[1]
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Dosage:7.5 μmol/kg; 7.5 μmol/h·kg
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Administration:i.v. bolus; constant-rate infusion
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Result:Showed no inhibitory effect on Gd-EOB-DTPA biliary excretion.
Resulted in 37.4% of Gd-EOB-DTPA dose excreted into bile 0-90 minutes post-administration.
Resulted in 39.1% of Gd-EOB-DTPA dose excreted renally.
Chemical Information
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CAS No. 41945-48-6
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Appearance Solid
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Molecular Weight 594.74
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Formula C28H47N2NaO8S
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Color White to off-white
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SMILES
O[C@H](C[C@@](C[C@H](O)CC1)([H])[C@@]1(C)[C@@]2([H])C[C@@H]3O)[C@@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCC(NCCS(=O)(O[Na])=O)=O)=O)([H])[C@]34C
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Synonyms
Tauroglycocholic acid sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 15.62 mg/mL (26.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
0.1 M HCl : 10 mg/mL (16.81 mM; ultrasonic and adjust pH to 1 with HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Schuhmann-Giampieri G, et al. Biliary excretion and pharmacokinetics of a gadolinium chelate used as a liver-specific contrast agent for magnetic resonance imaging in the rat. J Pharm Sci. 1993;82(8):799-803. [Content Brief]
[3]. Kouchak M, et al. Effects of various penetration enhancers on penetration of aminophylline through shed snake skin. Jundishapur J Nat Pharm Prod. 2014;9(1):24-29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M HCl / DMSO | 1 mM | 1.6814 mL | 8.4070 mL | 16.8141 mL | 42.0352 mL |
| 5 mM | 0.3363 mL | 1.6814 mL | 3.3628 mL | 8.4070 mL | |
| 10 mM | 0.1681 mL | 0.8407 mL | 1.6814 mL | 4.2035 mL | |
| 15 mM | 0.1121 mL | 0.5605 mL | 1.1209 mL | 2.8023 mL | |
| DMSO | 20 mM | 0.0841 mL | 0.4204 mL | 0.8407 mL | 2.1018 mL |
| 25 mM | 0.0673 mL | 0.3363 mL | 0.6726 mL | 1.6814 mL |
Sodium tauroglycocholate Related Classifications
Cat. No.: HY-B2119
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- Sodium tauroglycocholate
- 41945-48-6
- Tauroglycocholic acid
- Biochemical Assay Reagents
- aminophylline
- rats
- Gd-EOB-DTPA
- shed Vipera labatina snake skin
- stratum corneum lipid bilayer components
- male Wistar-Han rats
- corneocytes
- keratin filaments
- hepatocyte biliary acid transporting systems
- invertase
- Inhibitor
- inhibitor
- inhibit