11-Hydroxytephrosin
Based on 1 Customer Validation
11-Hydroxytephrosin is a potent NF-κB inhibitor with an IC50 of 0.19 μM or 4.21 μM. 11-Hydroxytephrosin is isolated from A. fruticosa. 11-Hydroxytephrosin inhibits the activation of NF-κB. 11-Hydroxytephrosin can be used in research related to cervical cancer and inflammatory diseases.
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- Purity: 98.0%
- CAS No.: 72458-85-6
- 화학식: C23H22O8
- 분자량:426.42
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.19 μM
Compound: 2
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Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay
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[PMID: 18841906] |
| RAW264.7 | IC50 |
4.21 μM
Compound: 2
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Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay
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[PMID: 18841906] |
11-Hydroxytephrosin (24 h) potently inhibits TNF-α-induced NF-κB activation in HeLa cells with an IC50 of 0.19 μM, and shows no significant cytotoxicity at concentrations up to 30 μM[1].
11-Hydroxytephrosin (24 h) inhibits LPS-induced NF-κB activation in RAW264.7 cells with an IC50 of 4.21 μM, and shows no significant cytotoxicity at concentrations up to 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 72458-85-6
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Appearance Solid
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분자량 426.42
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화학식 C23H22O8
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Color White to off-white
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SMILES
O=C1[C@]2(O)[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC(O)=C14
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
순도&문서
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
11-Hydroxytephrosin Related Classifications
HY-N1022 Related Classifications
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