ABT-255 free base
ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis.
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- CAS No.: 186293-38-9
- 화학식: C21H24FN3O3
- 분자량:385.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
ABT-255 (0.016-0.5 μg/mL) free base shows MIC values of 0.016 μg/mL against ATCC 35801, 0.031 μg/mL against ATCC 25618, and 0.031 μg/mL against both 35837b (Ethambutol (HY-B0535)-resistant) and 35838c (Rifampin (HY-B0272)-resistant)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4- to 6-week-old female CF-1 mice were intraperitoneally injected with overnight cultures of Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli JUHL, with the inoculum adjusted to approximately 100 times the 50% lethal dose[1]
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Dosage:3.13, 6.25, 12.5, 25 mg/kg
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Administration:p.o. once daily for 4 weeks
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Result:Reduced Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli in mice JUHL.
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Animal Model:4- to 6-week-old female CF-1 mice were intravenously injected via the caudal tail vein with approximately 107 viable M. tuberculosis cells suspended in 0.2 mL of modified 7H10 broth[1]
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Dosage:6.25, 12.5, 25 mg/kg
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Administration:p.o. once daily for 4 weeks
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Result:Produced a dose-responsive 0- to 5.5-log reduction in M. tuberculosis (ATCC 35801) counts in lung tissue.
Produced a dose-related 1- to 3-log reduction in viable Ethambutol (HY-B0535)-resistant M. tuberculosis (ATCC 35837) counts in lung tissue.
Produced a dose-responsive 1- to 2.5-log reduction in viable Rifampin (HY-B0272)-resistant Mycobacterium tuberculosis (ATCC 35838) counts in lung tissue.
Chemical Information
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CAS No. 186293-38-9
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분자량 385.43
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화학식 C21H24FN3O3
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SMILES
O=C(C1=CC(C2CC2)=C3C(C)=C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)C(F)=CN3C1=O)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABT-255 free base Related Classifications
HY-113619 Related Classifications
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