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Cat. No.: HY-N21828

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Annonin VI

Annonin VI is an inhibitor of NADH:ubiquinone oxidoreductase (complex I; complex I) and glucose:ubiquinone oxidoreductase discovered in the seeds of Annona squamosa. Annonin VI exhibits an IC₅₀ of 0.02 nmol/mg protein against bovine heart complex I, and an IC₅₀ of 12.4 nmol/mg protein against glucose dehydrogenase (GDH) derived from Gluconobacter oxydans. Annonin VI acts in a partially competitive manner on the region associated with the ubiquinone catalytic site of complex I, blocking electron transfer from high-potential iron-sulfur clusters to ubiquinone. Annonin VI binds competitively with ubiquinone at the homologous ubiquinone site on GDH. Annonin VI can be used in the research of bacterial infections, insecticides, and cancer.

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CAS No.: 129212-94-8
화학식: C₃₇H₆₆O₇
분자량:622.92

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Annonin VI Chemical Structure

CAS No.: 129212-94-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Annonin VI (1 min) potently inhibits NADH:ubiquinone oxidoreductase (complex I) from bovine heart (IC₅₀ 0.02 nmol/mg protein), the corresponding enzyme from Escherichia coli (IC₅₀ 0.02 nmol/mg protein), and the corresponding enzyme from Neurospora crassa (IC₅₀ 0.2 nmol/mg protein), and simultaneously inhibits glucose:ubiquinone oxidoreductase from Gluconobacter oxidans (IC₅₀ 12.4 nmol/mg protein)^[2].
Annonin VI (0-10 nM) inhibits bovine heart NADH:ubiquinone oxidoreductase in a partially competitive manner and inhibits glucose:ubiquinone oxidoreductase from Gluconobacter oxidans in a competitive manner, with both inhibitory effects targeting ubiquinone-2^[2].
Annonin VI (compound 2) is an acetogenin derived from the seeds of Annona squamosa, and its structure consists of a hydroxylated bis-tetrahydrofuran core and an α,β-unsaturated-γ-lactone moiety^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 129212-94-8
분자량 622.92
화학식 C₃₇H₆₆O₇
SMILES

O=C1C(CC(O)CCCCCCCCCC[C@H]([C@]2([H])O[C@@H]([C@@H]3O[C@@](CC3)([H])[C@@H](O)CCCCCCCCCC)CC2)O)=C[C@H](C)O1
Structure Classification
- Others
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nonfon M, et al. Four annonins from Annona squamosa[J]. Phytochemistry, 1990, 29(6): 1951-1954.

[2]. Friedrich T, et al. Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. Eur J Biochem. 1994 Jan 15;219(1-2):691-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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