Antibacterial agent 96
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells.
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- CAS No.: 2413006-62-7
- 화학식: C18H15Cl2NO2
- 분자량:348.22
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
14.4 μM
Compound: 4k
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 32113048] |
| HepG2 | CC50 |
14.9 μM
Compound: 4k
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by neutral red uptake assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by neutral red uptake assay
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[PMID: 32113048] |
| Vero | CC50 |
>20 μM
Compound: 4k
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 32113048] |
| Vero | CC50 |
>20 μM
Compound: 4k
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by neutral red uptake assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by neutral red uptake assay
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[PMID: 32113048] |
In Vitro
Antibacterial agent 96 shows antibacterial activity with an MIC value of 0.3, 0.2, 0.5, 0.2, 14.4 μM for Mycobacterium tuberculosis (M. tuberculosis) H37RvPT2, PT12, PT20, qcrB-T313A strain, respectively[1].
Antibacterial agent 96 shows toxicity with CC50s of 14.4, >20 μM for HepG2 and Vero cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2413006-62-7
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분자량 348.22
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화학식 C18H15Cl2NO2
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SMILES
COC1=CC2=C(N=C(C=C2OCC3=CC=C(C(Cl)=C3)Cl)C)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 96 Related Classifications
HY-146374 Related Classifications
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