Anvatabart
Based on 1 Customer Validation
Anvatabart is an anti-ERBB2 human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.15%
- CAS No.: 2636710-06-8
- 분자량:145.454 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
제품 설명
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
ERBB2/HER2/CD340
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Anvatabart on AHC2 biosensor, can bind HER2/CD340 Protein, Human (HEK293, His, HY-P70254) with an affinity constant of 1.171E-09 M as determined in BLI assay. -
Immobilized HER2/CD340 Protein, Human (HEK293, His, HY-P70254) can bind Anvatabart. The EC50 for this effect is 25.9 ng/mL. -
Flow cytometric analysis of 1×106 MCF-7 cells with Anvatabart (HY-P990697, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Loaded Anvatabart on Sensor Chip Protein A, can bind HER2/CD340 Protein, Human (HEK293, HY-P70254U) with an affinity constant of 1.30E-09 M as determined in SPR assay.
Chemical Information
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CAS No. 2636710-06-8
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Appearance Liquid
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분자량 145.454 kDa
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Color Colorless to light yellow
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Synonyms
ARX-788
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Anvatabart
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)