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Cat. No.: HY-148174

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JNJ-3790339

JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC₅₀ of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation.

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CAS No.: 93076-87-0
화학식: C₃₀H₃₃N₃OS
분자량:483.67

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

JNJ-3790339 Chemical Structure

CAS No.: 93076-87-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 9.6 μM (DGKα)^[1]

In Vitro

JNJ-3790339 (5-40 μM; 48 h) exhibits cytotoxic efficacy against A375, U251 and Jurkat T^[1].
JNJ-3790339 (5 μM; 6 h) promotes activation of primary murine T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A375, U251 and Jurkat T
Concentration:

5, 15, 25 and 40 μM
Incubation Time:

48 h
Result:

Exhibited cytotoxic efficacy against cancer cells in a dose-dependent manner.

RT-PCR^[1]

Cell Line:

Jurkat T
Concentration:

5 μM
Incubation Time:

6 h
Result:

Displayed high activation response with significantly increased CD69 and TNFα expression.

Chemical Information

CAS No. 93076-87-0
분자량 483.67
화학식 C₃₀H₃₃N₃OS
SMILES

O=C1C(CCN2CC/C(CC2)=C(C3=CC=C(C)C=C3)\C4=CC=C(C)C=C4)=C(C)N=C5SC=C(C)N51
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Granade ME, et al. Identification of ritanserin analogs that display DGK isoform specificity. Biochem Pharmacol. 2022 Mar;197:114908. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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