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Pacanalotamab

(Synonyms: AMG 420; BI-836909)
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Based on 1 Customer Validation

Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3E. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines.

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  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pacanalotamab
  • Experimental Validation Results for Pacanalotamab
  • Experimental Validation Results for Pacanalotamab
  • Experimental Validation Results for Pacanalotamab
  • Pacanalotamab Chemical Structure
    Pacanalotamab Chemical Structure
CAS No.: 2251756-52-0
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

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Pacanalotamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)

  • 1/16

    Immobilized Pacanalotamab can bind Human BCMA Protein (ECD, hFc Tag). The EC50 for this effect is 0.597 ng/mL.

  • 1/16

    Immobilized Pacanalotamab can bind Human CD3 epsilon/CD3e Protein (ECD, hFc Tag). The EC50 for this effect is 1.506 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pacanalotamab (HY-P99798). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Pacanalotamab Chemical Structure
    1/16
  • Pacanalotamab
  • Immobilized Pacanalotamab can bind Human BCMA Protein (ECD, hFc Tag). The EC50 for this effect is 0.597 ng/mL.
  • Immobilized Pacanalotamab can bind Human CD3 epsilon/CD3e Protein (ECD, hFc Tag). The EC50 for this effect is 1.506 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pacanalotamab (HY-P99798). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)