Paclobutrazol
Based on 2 publication(s) in Google Scholar
Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. Paclobutrazol also has antifungal activities. Paclobutrazol, transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants. Paclobutrazol is typically used to support research on the role of gibberellins in plant biology.
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- Purity: 97.38%
- CAS No.: 76738-62-0
- 화학식: C15H20ClN3O
- 분자량:293.79
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
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Publications Citing Use of MedChemExpress (MCE) Paclobutrazol
More
Biological Activity
Paclobutrazol (Foliar spraying, 5-20 μg/mL) increases total soluble sugars, starch, protein and free amino acids in mature seeds of Brassica juncea[1].
Paclobutrazol (0-19.8 μg·AI/mL) inhibits the growth of a panel of fungis (such as Sirococcus clavigignenti-juglandacearum and Ceratocystis fagacearum)[2].
Paclobutrazol (5-100 μg/mL, 7-21 days) improves the quality of tomato seedlings and induces resistance to early blight disease[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 76738-62-0
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Appearance Solid
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분자량 293.79
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화학식 C15H20ClN3O
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Color White to off-white
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SMILES
O[C@@H](C(C)(C)C)[C@@H](N1N=CN=C1)CC2=CC=C(Cl)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
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Journal Impact Factor
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Most Recent
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EMBO J
A regulatory module mediating temperature control of cell-cell communication facilitates tree bud dormancy release. [Abstract]2024 Dec;43(23):5793-5812. PMID: 39363036 -
Curr Biol
ELF3 coordinates temperature and photoperiodic control of seasonal growth in hybrid aspen. [Abstract]2025 Apr 7;35(7):1484-1494.e2. PMID: 40054469
용액&용해도
DMSO : 250 mg/mL (850.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (251 KB)
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SDS (774 KB)
- English - EN (774 KB)
- Français - FR (774 KB)
- Deutsch - DE (774 KB)
- Norwegian - NO (774 KB)
- Español - ES (774 KB)
- Swedish - SV (774 KB)
- Italian - IT (774 KB)
- Korean - KR (774 KB)
- Portuguese - PT (774 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4038 mL | 17.0190 mL | 34.0379 mL | 85.0948 mL |
| 5 mM | 0.6808 mL | 3.4038 mL | 6.8076 mL | 17.0190 mL | |
| 10 mM | 0.3404 mL | 1.7019 mL | 3.4038 mL | 8.5095 mL | |
| 15 mM | 0.2269 mL | 1.1346 mL | 2.2692 mL | 5.6730 mL | |
| 20 mM | 0.1702 mL | 0.8509 mL | 1.7019 mL | 4.2547 mL | |
| 25 mM | 0.1362 mL | 0.6808 mL | 1.3615 mL | 3.4038 mL | |
| 30 mM | 0.1135 mL | 0.5673 mL | 1.1346 mL | 2.8365 mL | |
| 40 mM | 0.0851 mL | 0.4255 mL | 0.8509 mL | 2.1274 mL | |
| 50 mM | 0.0681 mL | 0.3404 mL | 0.6808 mL | 1.7019 mL | |
| 60 mM | 0.0567 mL | 0.2836 mL | 0.5673 mL | 1.4182 mL | |
| 80 mM | 0.0425 mL | 0.2127 mL | 0.4255 mL | 1.0637 mL | |
| 100 mM | 0.0340 mL | 0.1702 mL | 0.3404 mL | 0.8509 mL |
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