N-1-Naphthylphthalamic acid
Based on 4 publication(s) in Google Scholar
N-1-Naphthylphthalamic acid (Alanap 1) is a modulator of polar auxin transport that competes with auxin (indole-3-acetic acid, IAA) for membrane binding sites. N-1-Naphthylphthalamic acid also disrupts maize leaf initiation, KNOX protein regulation, and leaf margin formation.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 132-66-1
- Formula: C18H13NO3
- Molecular Weight:291.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N-1-Naphthylphthalamic acid
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Customer Validation & Images
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Others
Biological Activity
N-1-Naphthylphthalamic acid (0.01-100 μM; 1 h) stimulates net uptake of [(3)H]IAA by maize coleoptile tissue at low concentrations (<10 μM) and inhibits the uptake of [(3)H]IAA and [(14)C]benzoic acid at high concentrations (>100 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 132-66-1
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Appearance Solid
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Molecular Weight 291.31
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Formula C18H13NO3
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Color White to off-white
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SMILES
O=C(C1=CC=CC=C1C(NC2=C3C=CC=CC3=CC=C2)=O)O
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Synonyms
Alanap 1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Rep
Viral action on the auxin signaling repressor IAA16 reveals a conserved negative regulator of plant growth and immunity. [Abstract]2026 Feb 23;45(3):117034. PMID: 41734062
N-1-Naphthylphthalamic acid purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Feb 23;45(3):117034. [Abstract]
The relative content of CLCuMuV in *Nicotiana benthamiana* plants inoculated with CLCuMuV-CLCuMuB and DMSO (control), or 1 or 100 μM NPA (N-1-Naphthylphthalamic acid).
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Plant Physiol Biochem
Target of rapamycin coordinates auxin are involved in exogenous melatonin regulated low temperature tolerance in cucumber seedlings. [Abstract]2024 Aug 16:215:109055. PMID: 39182426 -
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Solvent & Solubility
DMSO : 33.33 mg/mL (114.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (399 KB)
- English - EN (399 KB)
- Français - FR (399 KB)
- Deutsch - DE (399 KB)
- Norwegian - NO (399 KB)
- Español - ES (399 KB)
- Swedish - SV (399 KB)
- Italian - IT (399 KB)
- Korean - KR (399 KB)
- Portuguese - PT (399 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.4328 mL | 17.1638 mL | 34.3277 mL | 85.8192 mL |
| 5 mM | 0.6866 mL | 3.4328 mL | 6.8655 mL | 17.1638 mL | |
| 10 mM | 0.3433 mL | 1.7164 mL | 3.4328 mL | 8.5819 mL | |
| 15 mM | 0.2289 mL | 1.1443 mL | 2.2885 mL | 5.7213 mL | |
| 20 mM | 0.1716 mL | 0.8582 mL | 1.7164 mL | 4.2910 mL | |
| 25 mM | 0.1373 mL | 0.6866 mL | 1.3731 mL | 3.4328 mL | |
| 30 mM | 0.1144 mL | 0.5721 mL | 1.1443 mL | 2.8606 mL | |
| 40 mM | 0.0858 mL | 0.4291 mL | 0.8582 mL | 2.1455 mL | |
| 50 mM | 0.0687 mL | 0.3433 mL | 0.6866 mL | 1.7164 mL | |
| 60 mM | 0.0572 mL | 0.2861 mL | 0.5721 mL | 1.4303 mL | |
| 80 mM | 0.0429 mL | 0.2145 mL | 0.4291 mL | 1.0727 mL | |
| 100 mM | 0.0343 mL | 0.1716 mL | 0.3433 mL | 0.8582 mL |
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