(±)11(12)-EET
Based on 1 Customer Validation
(±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.33%
- CAS No.: 87173-81-7
- 화학식: C20H32O3
- 분자량:320.47
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보관:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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HY-132184
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Isodeoxycholic acidEndogenous Metabolite -
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(±)10(11)-EDP ethanolamide -
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(±)17(18)-EpETE-ethanolamide -
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Isodeoxycholic acid (Standard)Standard
Biological Activity
제품 설명
IC50 & Target
[1]|
NLRP3 inflammasome |
In Vitro
(±)11(12)-EET (5 μM; 10 mimutes; macrophages) depresses NLRP3 protein expression, dramatically decreases the expression of pro-IL-1β in cells and the supernatant and reduces the intracellular ROS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87173-81-7
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Appearance Liquid
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분자량 320.47
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화학식 C20H32O3
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C[C@H]1O[C@H]1C/C=C\C/C=C\CCCC(O)=O
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Synonyms
11,12-EET
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
순도&문서
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Data Sheet (271 KB)
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SDS (546 KB)
- English - EN (546 KB)
- Français - FR (546 KB)
- Deutsch - DE (546 KB)
- Norwegian - NO (546 KB)
- Español - ES (546 KB)
- Swedish - SV (546 KB)
- Italian - IT (546 KB)
- Korean - KR (546 KB)
- Portuguese - PT (546 KB)
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Handling Instructions (2659 KB)
References
[1]. Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921. [Content Brief]
[2]. Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922. [Content Brief]
[3]. Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257(7):3771-3781. [Content Brief]
[4]. Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41(2):163-181. [Content Brief]
[5]. Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294(6):F1441-F1447. [Content Brief]
[6]. Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl(Suppl):S52-S56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)11(12)-EET Related Classifications
HY-130494 Related Classifications
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