RP-182 acetate
Based on 1 Customer Validation
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research.
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- 화학식: C69H103N19O11·xC2H4O2
- 분자량:1374.68 (free base)
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
RP-182 acetate (1 nM-1 mM, 48 h) increases cell killing of CD206high M2-like macrophages with an IC50 of 17.6 μM through the MyD88/NF-κB pathway[1][2].
RP-182 acetate (0.1 μM, 2-24 h) internalizes CD206, activated NF-κB, and increased IRF7 phosphorylation in IL-4-polarized M2 bone marrow-derived macrophages[1][2].
RP-182 acetate (3-30 μM, 24 h) increases levels of inflammatory factors secreted by macrophages, indicating immune reprogramming[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Macrophages
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Concentration:3, 10 and 30 μM
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Incubation Time:24 h
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Result:Increased the levels of TNFα and IFNγ.
RP-182 acetate (20 mg/kg, i.p., once daily for 18 days) significantly alleviates pulmonary fibrosis in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16 melanoma allograft and KP16 pancreatic model established in eight- to twelve-week old C57B/L6 mice[1]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection (i.p.), every other day for 2 weeks
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Result:Inhibited tumor growth and prolonged median survival in mice
Increased CD8+ T cell infiltration.
Significantly increased IFN-γ secretion by CD8+ T cells in tumors.
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Animal Model:B16 melanoma allograft and KP16 pancreatic model established in eight- to twelve-week old C57B/L6 mice[1]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection (i.p.), every other day for 2 weeks
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Result:Inhibited tumor growth and prolonged median survival in mice
Increased CD8+ T cell infiltration.
Significantly increased IFN-γ secretion by CD8+ T cells in tumors.
Chemical Information
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Appearance Solid
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분자량 1374.68 (free base)
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화학식 C69H103N19O11·xC2H4O2
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Sequence
Lys-Phe-Arg-Lys-Ala-Phe-Lys-Arg-Phe-Phe
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Sequence Shortening
KFRKAFKRFF
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
순도&문서
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Data Sheet (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RP-182 acetate Related Classifications
HY-P11108A Related Classifications
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