tDHU, acid
Based on 1 Customer Validation
tDHU, acid is a type of dihydropyrimidine Cereblon ligand and a benzoic acid linker conjugate, which can be used in the development of PROTACs.
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- Purity: 98.83%
- CAS No.: 2377643-37-1
- 화학식: C12H12N2O4
- 분자량:248.23
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>50 μM
Compound: tDHU-CO2H
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Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins by cell titer-glo assay
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[PMID: 35859867] |
| HEK293 | IC50 |
>50 μM
Compound: tDHU-CO2H
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Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
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[PMID: 35859867] |
| HEK293 | IC50 |
1.94 μM
Compound: tDHU-CO2H
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Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
Cytotoxicity against permeabilized HEK293 cells assessed as inhibition of cell viability incubated for 30 mins in presence of CRBN-tracer by nanoBRET assay
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[PMID: 35859867] |
tDHU, acid is a click chemistry reagent. tDHU, acid contains an Azide group, which can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. tDHU, acid can also undergo a ring tension-driven acetylene-azide cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2377643-37-1
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Appearance Solid
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분자량 248.23
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화학식 C12H12N2O4
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Color White to off-white
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SMILES
O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 17.5 mg/mL (70.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0285 mL | 20.1426 mL | 40.2852 mL | 100.7131 mL |
| 5 mM | 0.8057 mL | 4.0285 mL | 8.0570 mL | 20.1426 mL | |
| 10 mM | 0.4029 mL | 2.0143 mL | 4.0285 mL | 10.0713 mL | |
| 15 mM | 0.2686 mL | 1.3428 mL | 2.6857 mL | 6.7142 mL | |
| 20 mM | 0.2014 mL | 1.0071 mL | 2.0143 mL | 5.0357 mL | |
| 25 mM | 0.1611 mL | 0.8057 mL | 1.6114 mL | 4.0285 mL | |
| 30 mM | 0.1343 mL | 0.6714 mL | 1.3428 mL | 3.3571 mL | |
| 40 mM | 0.1007 mL | 0.5036 mL | 1.0071 mL | 2.5178 mL | |
| 50 mM | 0.0806 mL | 0.4029 mL | 0.8057 mL | 2.0143 mL | |
| 60 mM | 0.0671 mL | 0.3357 mL | 0.6714 mL | 1.6786 mL |
tDHU, acid Related Classifications
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