L-Cystine disodium monohydrate
Based on 1 Customer Validation
L-Cystine disodium monohydrate is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine disodium monohydrate elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine disodium monohydrate reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine disodium monohydrate combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine disodium monohydrate is promising for research of cystinuria and kidney stones.
For research use only. We do not sell to patients.
- CAS No.: 199329-53-8
- Formula: C6H12N2Na2O5S2
- Molecular Weight:302.28
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
L-Cystine (83 µM or 200 µM, 24 h or 72 h) disodium monohydrate effectively reverses the growth inhibition of both Sulfasalazine (HY-14655) and Erastin (HY-15763) in Huh6 cells[1]. L-Cystine ( 0.8 mM, 4 h) disodium monohydrate induces Nrf2 protein expression elevation in a Keap1-dependent manner in HeLa cells[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh6 and Huh7 cells
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Concentration:83 µM or 200 µM
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Incubation Time:72 h or 24 h
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Result:The degree of growth inhibition by Sulfasalazine (HY-14655) or Erastin (HY-15763) was greater in medium containing a physiological level of 83 μM L-cystine than in medium containing 200 μM L-cystine in Huh6 and Huh7 cells.
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Cell Line:HeLa cells
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Concentration:0.2 mM, 0.8 mM
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Incubation Time:4 h
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Result:Was sufficient for producing Nrf2 protein elevation at 0.2 mM in HeLa cells. Induced Nrf2 in a Keap1-dependent manner in HeLa cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nine-week-old female BALB/c mice[2]
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Dosage:140, 280 and 560 mg/kg
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Administration:p.o. administration for 11 days
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Result:Significantly increased IgG and IgM antibody production administrated with L-theanine (HY-15121) after DNP-dextran and DNP-KLH antigenic stimulation in mice.
Chemical Information
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CAS No. 199329-53-8
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Appearance Solid
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Molecular Weight 302.28
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Formula C6H12N2Na2O5S2
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Color White to off-white
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SMILES
N[C@@H](CSSC[C@H](N)C(O[Na])=O)C(O[Na])=O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Abdullah M, et al. Extracellular Concentration of L-Cystine Determines the Sensitivity to System xc- Inhibitors[J]. Biomol Ther (Seoul). 2022 Mar 1;30(2):184-190. [Content Brief]
[2]. Kurihara S, et al. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine[J]. J Vet Med Sci. 2007 Dec;69(12):1263-70. [Content Brief]
[4]. Greth WE, et al. Cellular accumulation of L-cystine in rat kidney cortex in vivo[J]. J Clin Invest. 1973 Feb;52(2):454-62. [Content Brief]
[5]. Ohtsu I, et al. Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. PLoS One. 2015 Apr 2;10(3):e0120619. [Content Brief]
[6]. Dai W, et al. Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture[J]. Cells. 2023 Jan 12;12(2):291. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Cystine disodium monohydrate Related Classifications
HY-W772717 Related Classifications
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