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Cat. No.: HY-18957B

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Lifirafenib maleate

Name: Lifirafenib maleate
Brand: MedChemExpress
SKU: HY-18957B
Availability: PreOrder

(Synonyms: BGB-283 maleate)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC₅₀ values of 23 and 29 nM for recombinant BRaf^V600E and EGFR, respectively.

For research use only. We do not sell to patients.

CAS No.: 1854985-74-2
Formula: C₂₅H₁₇F₃N₄O₃.3/2C₄H₄O₄
Molecular Weight:652.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Lifirafenib maleate Chemical Structure

CAS No.: 1854985-74-2

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC₅₀ values of 23 and 29 nM for recombinant BRaf^V600E and EGFR, respectively^[1].

IC₅₀ & Target

IC50: 23 nM (recombinant BRafV600E ), 29 nM (EGFR)^[1]

All EGFR Isoforms :

All Raf Isoforms :

Chemical Information

CAS No. 1854985-74-2
Molecular Weight 652.53
Formula C₂₅H₁₇F₃N₄O₃.3/2C₄H₄O₄
SMILES

O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.O=C(/C=C/C(O)=O)O.[1.5]
Synonyms

BGB-283 maleate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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J Mol Med (Berl)

The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis. [Abstract]

2026 Apr 23;104(1):68. PMID: 42020785
J Med Virol

Small molecule RAF265 as an antiviral therapy acts against HSV-1 by regulating cytoskeleton rearrangement and cellular translation machinery. [Abstract]

2023 Jan;95(1):e28226. PMID: 36251738
bioRxiv

A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia. [Abstract]

2025 May 3:2025.04.29.651188. PMID: 40654850

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang Z, et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Lifirafenib maleate

3 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Purity & Documentation
References

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Lifirafenib maleate

Publications Citing Use of MedChemExpress (MCE) Lifirafenib maleate

All EGFR Isoforms

All Raf Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

Lifirafenib maleate Related Classifications

HY-18957B Related Classifications

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