2. JAK/STAT Signaling MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. EGFR Raf
  4. Lifirafenib maleate

Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.

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Lifirafenib maleate

Lifirafenib maleate Estructura química

No. CAS : 1854985-74-2

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Lifirafenib maleate Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Descripciòn

Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively[1].

IC50 & Target

IC50: 23 nM (recombinant BRafV600E ), 29 nM (EGFR)[1]
Peso molecular

652.53

Fòrmula

C25H17F3N4O3.3/2C4H4O4
No. CAS
SMILES

O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.O=C(/C=C/C(O)=O)O.[1.5]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Lifirafenib maleate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lifirafenib1854985-74-2BGB-283BGB283BGB 283EGFRRafEpidermal growth factor receptorErbB-1HER1Raf kinasesrecombinant BRafInhibitorinhibitorinhibit

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Nombre del producto:
Lifirafenib maleate
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HY-18957B
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