2. JAK/STAT Signaling MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. EGFR Raf
  4. Lifirafenib maleate

Lifirafenib maleate  (Synonyms: BGB-283 maleate)

Cat. No.: HY-18957B
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Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.

For research use only. We do not sell to patients.

Lifirafenib maleate Chemical Structure

Lifirafenib maleate Chemical Structure

CAS No. : 1854985-74-2

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Lifirafenib maleate Related Antibodies

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1 Publications Citing Use of MCE Lifirafenib maleate

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Description

Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively[1].

IC50 & Target

IC50: 23 nM (recombinant BRafV600E ), 29 nM (EGFR)[1]
Molecular Weight

652.53

Formula

C25H17F3N4O3.3/2C4H4O4
CAS No.
SMILES

O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.O=C(/C=C/C(O)=O)O.[1.5]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lifirafenib maleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lifirafenib1854985-74-2BGB-283BGB283BGB 283EGFRRafEpidermal growth factor receptorErbB-1HER1Raf kinasesrecombinant BRafInhibitorinhibitorinhibit

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