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Cat. No.: HY-18957A

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rel-Lifirafenib

(Synonyms: rel-BGB-283)

rel-Lifirafenib (rel-BGB-283) is the relative configuration of Lifirafenib (HY-18957). Lifirafenib is a potent Raf Kinase and EGFR inhibitor.

For research use only. We do not sell to patients.

CAS No.: 1446090-77-2
Formula: C₂₅H₁₇F₃N₄O₃
Molecular Weight:478.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

rel-Lifirafenib Chemical Structure

CAS No.: 1446090-77-2

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Antibody-Drug Conjugates

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Biological Activity

Description

rel-Lifirafenib (rel-BGB-283) is the relative configuration of Lifirafenib (HY-18957). Lifirafenib is a potent Raf Kinase and EGFR inhibitor^[1].

All Raf Isoforms :

All EGFR Isoforms :

Chemical Information

CAS No. 1446090-77-2
Molecular Weight 478.42
Formula C₂₅H₁₇F₃N₄O₃
SMILES

O=C1NC2=NC=CC(OC3=CC=C(O[C@]4([H])[C@@]5([H])[C@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.[Relative stereochemistry]
Synonyms

rel-BGB-283
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tang Z, et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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rel-Lifirafenib

All Raf Isoforms

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

rel-Lifirafenib Related Classifications

HY-18957A Related Classifications