Small molecule-LNP

TNT-b10 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). TNT-b10 is a carrier for both siRNA and mRNA.

RM 137-15 is an ionizable lipid. The ability of ionizable lipids to form unstable non-bilayer structures at acidic pH is key for endosomal escape and cytosolic delivery of RNA. RM 137-15 can be used in the preparation of liposomes.

AL-A12 is a short-chain amino lipid with high gene delivery efficiency and low toxicity, and can be used in drug delivery research.

cKK-E15 is a peptide-lipid that can be used to formulate LNP3 with C14PEG2000, unmodified cholesterol, and DOPE.

C12-4 is an ionizable lipid for lipid nanoparticles (LNPs) formulation.

C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases.

Genevant CL1 monohydrochloride is an ionizable lipid (pKa = 6.3) suitable for the preparation of lipid nanoparticles (LNPs) for delivering nucleic acid payloads and intramuscular vaccines. Genevant CL1 monohydrochloride is a component of lipid nanoparticle delivery systems for mRNA vaccines.

LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids.

50-C2-C9-4tail has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo.

Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).

FTT5 LLNs are functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing.

Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.

C13-112-tetra-tail is a cationic lipid-like compound containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tetra-tail can be formulated into a lipid nanoparticle (LNP).

C13-112-tri-tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. C13-112-tri-tail can be formulated into a lipid nanoparticle (LNP).

A2-Iso5-4DC19 is a lipidoid compound. A2-Iso5-4DC19 is an effective carrier for the delivery of an agent such as a polynucleotide to a cell.

L343 is an ionizable cationic lipidoid and can be used to synthetic liposomes for systemic delivery of RNAi therapeutics.

14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery.

16:0-18:1 EPC chloride is a cationic lipid, which can be used for liposomes applied in drug delivery.

C13-113-tri tail is a cationic lipid-like compound containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. C13-113-tri tail can be formulated into a lipid nanoparticle (LNP).

GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research.