1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. mAChR-IN-1 hydrochloride

mAChR-IN-1 hydrochloride 

Cat. No.: HY-12426A Purity: 99.94%
Handling Instructions

mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.

For research use only. We do not sell to patients.

mAChR-IN-1 hydrochloride Chemical Structure

mAChR-IN-1 hydrochloride Chemical Structure

CAS No. : 119391-73-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 404 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM[1].

IC50 & Target

IC50: 17 nM (mAChR)[1].

Molecular Weight

524.82

Formula

C₂₃H₂₆ClIN₂O₂

CAS No.

119391-73-0

SMILES

O=C(C(C1CCN(CC2=CC=C(I)C=C2)CC1)(C3=CC=CC=C3)CC4)NC4=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 65 mg/mL (123.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9054 mL 9.5271 mL 19.0542 mL
5 mM 0.3811 mL 1.9054 mL 3.8108 mL
10 mM 0.1905 mL 0.9527 mL 1.9054 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
mAChR-IN-1 hydrochloride
Cat. No.:
HY-12426A
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